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3rd October 2015

Self-assembling material could lead to artificial veins

Researchers at Queen Mary University London (QMUL) have demonstrated a self-assembling organic material that grows and changes shape and which could lead to artificial veins.

 

self assembling organic material artificial arteries
Illustration showing creation of synthetic capillaries from peptides and proteins. Credit: QMUL

 

Researchers at Queen Mary University of London have developed a way of assembling organic molecules into complex, tubular, tissue-like structures, without the use of moulds or techniques like 3D printing.

The study, published this week in the journal Nature Chemistry, describes how peptides and proteins can be used to create materials that exhibit dynamic behaviours found in biological tissues – like growth, morphogenesis, and healing.

 

self assembling organic material artificial arteries
Credit: QMUL

 

The method uses solutions of peptide and protein molecules that, upon touching each other, self-assemble to form a dynamic tissue at the point at which they meet. As the material assembles itself, it can be easily guided to grow into complex shapes.

This discovery could lead to the engineering of tissues like veins, arteries, or even the blood-brain barrier, which would allow scientists to study diseases such as Alzheimer's with a high level of similarity to the real tissue, which is currently impossible. The technique could also contribute to the creation of better implants, complex tissues, or more effective drug screening methods.

 

self assembling organic material artificial arteries

 

Alvaro Mata, Director of the Institute of Bioengineering at QMUL, said: "What is most exciting about this discovery is the possibility for us to use peptides and proteins as building-blocks of materials with the capacity to controllably grow or change shape, solely by self-assembly."

Karla Inostroza-Brito, PhD student and first author of the paper, said: "The system is dynamic, so it can be triggered on demand to enable self-assembly with a high degree of control, which allows the creation of complex shapes with a structure that resembles elements of native tissue."

 

 

 

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