I honestly think there's as much chance of us being ruled by an religious fascist government that hate education, science and basic freedom by 2045 in such a way that progress could come to a stop or move backwards. Pretty much Trump without the restrictions on his power or the advancement of the current movement. Keep electing religious republicans and this will be our future.
Look at Turkey for a good example of this and how religion can stall science. Any futurist worth their salt needs to be able to admit that the future could be dark indeed. It isn't all peaches and creme! Believe me, I want to predict a perfect future where everyone is treated with respect and lives millions of years but humanity likely has a hell of a lot more blood to get through first.