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Anti aging thread


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#81
starspawn0

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One thing David Sinclair mentions in the above talk, but doesn't answer, is the following: if you age the brain of mice, does the epigenetic clock of other parts of the body age as well. In other words, are the clocks all coupled so tightly that aging in one organ affects the others?

If the answer is "yes", and if it also works in reverse, so that de-aging one organ somewhat de-ages the others (partially resets their clocks), then that would be a way to greatly slow aging! Basically, replace several organs with 3D-printed "young" copies; then, over time, all the other organs will become younger, too.

Perhaps, assuming that recent paper on HGH-induced age-reversal pans out, this is the cause: HGH caused the thymus to operate like when the person was young; which, in turn, caused the immune system to de-age (as measured by epigenetic clock).

#82
starspawn0

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https://mobile.twitt...046160480722944

You are looking at the #future. A device that will soon look like small bandaid & measure 100s of biomarkers, telling you what’s best to eat & when to get to the doctor, pushing diseases & frailty off into the future. #health #OptimalHealth #tech #fitness



#83
starspawn0

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From 2016: might be a way to protect DNA from reactive oxygen species:

https://www.newscien...ld-for-its-dna/

Given that DNA damage is claimed to be a major cause of aging (by David Sinclair), this might have life-extension effects.

#84
starspawn0

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Researchers Identify Cells that Drive Human Skin Aging

https://discoverysed...man-skin-aging/

Just think:. Senolytics could be a way to keep people looking young, by virtually eliminating wrinkles and other signs of skin aging.

Three authors report that they are employees of Unilever and state, “although no products were tested, this work could potentially promote the use of anti-aging products and lead to financial gain for Unilever.”


That's an understatement!

#85
starspawn0

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Perhaps this should be considered medical news, but I have a future sci-tech angle on it:
 
https://spectrum.iee...work-heart-rats

Bionic Pacemaker Controlled by Neural Network Reverses Heart Failure in Rats

....

In a paper published this week in the Journal of Physiology, Paton and his colleagues describe a smarter pacemaker that puts natural variation back into a failing heart, helping it to work more efficiently.

The device reads the electrical signals generated by each breath, and paces the heart accordingly. In rats with heart failure, the device increased the amount of blood their hearts could pump by 20%, compared with monotonic pacemaking, according to the study.


Might work in people. Here's my future take: why not do this for other organs, too, like the kidneys and liver? e.g. the body has ways of estimating how much insulin it will need, but sometimes it guesses wrong. What if by using deep neural nets that take in sensory input, they can stimulate and inhibit organs to where they react more efficiently? I bet it's possible. ​

#86
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https://youtu.be/E-IaSS0bbGU

Nov 14, 2019
Investor and entrepreneur Peter Thiel delivers the 2019 Wriston Lecture.

---------------------------------------------------------

Peter Thiel is 52 years old. He looks 22 years old. 



#87
starspawn0

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Two articles:
 
Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice 
 
https://www.ncbi.nlm...les/PMC5295690/

Astaxanthin appears to significantly slow skin photo-aging.

It appears to have lots of good effects on the body. If you take enough of it, it will settle in your body fat and make you look redder, just like how shrimp turn red. Beta Carotene and Canthaxanthin will likewise darken you skin, as they settle into your fat; and are used skin tan pills. It takes weeks for your skin to return to normal.

There is some risk, however: take too much, and there is a slight increased risk of cancer; and too much Canthaxanthin can cause crystals to form in your retina, that impair vision. But this appears to be rare.

....

Olive oil superfood may protect the brain from age-related dementia

https://www.slashgea...entia-25601431/

Mouse study shows that extra virgin olive oil can reduce bad brain Tau deposits by half. Might also hold in humans. It's known that diet can significantly improve brain health and slow aging.

#88
starspawn0

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I've been taking Astaxanthin, over 16 mg per day. I've noticed some subtle effects, but I'm not sure it is due to that supplement -- could be due to changes in the season.

The two effects I have noticed:

* My skin has changed color a little. Yellow and also slightly pink -- I'd say the color change is more yellowish than pink. If I keep taking it, hopefully it will look more brownish, which would resemble a tan.

* My skin feels a little "tighter". Perhaps "a little more waxy" is a better descriptor. When I pinch my arm, the surface of the skin feels slightly more waxy, and doesn't stretch as much as usual; resists stretching, and skin feels "thicker". My face feels smoother.

I've read that Astaxanthin improves skin by keeping it from drying out. I can see that -- the ever so subtle waxy coating would probably keep water from escaping, and that will have the effect of making skin look younger. I've noticed when using sun-screen, the oil improves my skin.

....

Anyways, I will repeat that these beneficial effects may not be due to Astaxanthin; but if not, I don't know what else would cause them -- and I'm not imagining it.

#89
Jessica

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Alzheimer’s Drugs Reverse Broader Aging

Brian Wang | December 13, 2019

 

In mouse models of Alzheimer’s disease, the drug candidates (CMS121 and J147) improve memory and slow the degeneration of brain cells. Researchers have shown how these compounds can also slow aging in healthy older mice, blocking the damage to brain cells that normally occurs during aging and restoring the levels of specific molecules to those seen in younger brains.

In the new research, Maher, Currais and their colleagues turned to a strain of mice that ages unusually fast. A subset of these mice was given CMS121 or J147 beginning at nine months old — the equivalent of late middle age in humans. After four months, the team tested the memory and behavior of the animals and analyzed genetic and molecular markers in their brains.

Not only did the animals given either of the drug candidates perform better on memory tests than mice that hadn’t received any treatment, but their brains showed differences at the cellular and molecular levels. In particular, expression of genes associated with the cell’s energy-generating structures called mitochondria was preserved by CMS121 and J147 with aging.

 

https://www.nextbigf...ader-aging.html



#90
Jessica

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Oisin and OncoSenX Antiaging Extends Life 20% Life Extension in Old Mice and Human Clinical Trial Early 2020f

https://www.nextbigf...medium=facebook

Brian Wang | October 31, 2019
Screen-Shot-2019-10-31-at-3.50.48-PM-730

Oisin and its spinout OncoSenX completed antiaging trials using synolytics to extend the life of old mice by 20%. They will have human clinical trials starting in early 2020. They will apply it to people with solid tumors.

They use a lipid nanoparticle to deliver a DNA plasmid into sensescent (aka zombie) cells. The old cells are triggered to die and this boosts health and longevity.

At Ending Age-Related Diseases, John Lewis of Oisin Biotechnologies discussed senolytics, which are drugs that kill senescent cells. He explained the differences between healthy and senescent cells along with the senescence-associated secretory phenotype (SASP) responsible for systemic inflammation. He went into detail about senolytics and what his company looks for when creating them, including details about suicide genes and biomarkers of senescence. He also discussed issues with bringing these drugs to humans and suggested oncology as a possible method for bringing them to the clinic.

 

Screen-Shot-2019-10-31-at-5.10.02-PM-102

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Screen-Shot-2019-10-31-at-3.58.28-PM-102



#91
Jessica

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Combination Gene Therapy Progressing Against Aging
Brian Wang | December 30, 2019
Screen-Shot-2019-12-30-at-12.19.21-PM-73

George Church indicates Rejuvenate Bio is working toward combination gene therapy against 300+ human genes that effect aging.

There is also progress in super-resolution imaging of chromosomes and hyper-detailed tissue analysis.

They will be able to analyze the DNA in the chromosome without breaking it up and knowing the exact position of the DNA.

Screen-Shot-2019-12-30-at-12.21.18-PM.jp

Screen-Shot-2019-12-30-at-12.18.28-PM.jp

Screen-Shot-2019-12-30-at-12.24.03-PM.jp

Microscopic imaging beyond the diffraction limit to 12 nanometers.

Screen-Shot-2019-12-30-at-12.24.32-PM.jp

The exponential biotechnology is scaling to the tissue and organ scale. It will then reach the full organism level.

 

https://www.nextbigf...inst-aging.html



#92
Jessica

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First supercentenarian-derived stem cells created

by Monica May, Sanford Burnham Prebys Medical Discovery Institute

People who live more than 110 years, called supercentenarians, are remarkable not only because of their age, but also because of their incredible health. This elite group appears resistant to diseases such as Alzheimer's, heart disease and cancer that still affect even centenarians. However, we don't know why some people become supercentenarians and others do not.

 

Now, for the first time, scientists have reprogrammed cells from a 114-year-old woman into induced pluripotent stem cells (iPSCs). The advance, completed by scientists at Sanford Burnham Prebys and AgeX Therapeutics, a biotechnology company, enables researchers to embark on studies that uncover why supercentenarians live such long and healthy lives. The study was published in Biochemical and Biophysical Research Communications.

"We set out to answer a big question: Can you reprogram cells this old?" says Evan Y. Snyder, M.D., Ph.D., professor and director of the Center for Stem Cells and Regenerative Medicine at Sanford Burnham Prebys, and study author. "Now we have shown it can be done, and we have a valuable tool for finding the genes and other factors that slow down the aging process."

 

https://phys.org/new...stem-cells.html



#93
Erowind

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Yoooo Jessica I'm really enjoying these infographs 



#94
Jessica

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They make it easy to understand what is being advanced. ;)

 

Rapid Aging Reversal Achieved With Human Cells

Brian Wang | March 25, 2020
 

Transient reprogramming, mediated by transient expression of mRNAs, promotes a rapid reversal of both cellular aging and of epigenetic clock in human fibroblasts and endothelial cells, reduces the inflammatory profile in human chondrocytes, and restores youthful regenerative response to aged, human muscle stem cells, in each case without abolishing cellular identity.

Old human cells can become more youthful by coaxing them to briefly express proteins used to make induced pluripotent cells, Stanford researchers and their colleagues have found. The finding may have implications for aging research. Elderly mice regained youthful strength after their existing muscle stem cells were subjected to the rejuvenating protein treatment and transplanted back into their bodies.

The proteins, known as Yamanaka factors, are commonly used to transform adult cells into induced pluripotent stem cells, or iPS cells. Induced pluripotent stem cells can become nearly any type of cell in the body, regardless of the cell from which they originated. They’ve become important in regenerative medicine and drug discovery.

 



#95
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We will hit LEV (Longevity Escape Velocity) in the 2030s because :

 

1) By 2030, we will have 100+ Senolytics on the market. That will add 5 years easily with a good combination of 20 or so.

 

2) By 2030, we will get CRISPR 4.0 or even a much better gene editing technic, editing genes on grown adults won't pose any technical problem. Adding/Replacing our genes with the best genes for health will add another 5 years.

 

3) In the 2030s, we will have 3D-printed organs and perfected stem cells therapies,  that's another 5 years.

 

4) We will get much more powerful predictive tools so that we get don't get cancers in the first place, we will get personalized medicine that works best for us. That's again 5 years.

 

5) AI drug discoveries and AI clinical trials simulation (InSillico) will shrink the classical long/costly FDA process of drug discovery/testing from 10-15 years to a few months. New therapies will come to market much more rapidly and a much faster pace. So in the 2030-2039, we will get as many new treatments than during the last 50 years.

 

All those technologies will add 20 years starting from now to 2040. So I think LEV in the 2030s is almost certain. What do you think ?



#96
tomasth

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Add 20 years to ANY age living now ?



#97
Raklian

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Let's all try to survive the next several pandemics before we can breathe easily and achieve LEV.


What are you without the sum of your parts?

#98
Erowind

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Anyone under 45ish has a good shot at reaching LEV and anyone in their early 20s and under almost a guaranteed shot imo. I'll believe it when I see it for the 2030s. I don't think kurzweil himself will make it but some lucky souls destined to naturally live past 110 who were born in the 1960s will. I think we'll hit LEV for sure by the 2070s and those folks will be clinging on then.

#99
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I'd say 2040s for the elites/super-rich, and then 2060s for mainstream adoption, by which time a lot of patents will be expiring.



#100
Erowind

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/\ I love the optimism! I don't like my slightly less optimistic prediction. I hope it happens in the 2040s or earlier and I can afford the treatment for my mom.




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