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Anti aging thread


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#81
starspawn0

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One thing David Sinclair mentions in the above talk, but doesn't answer, is the following: if you age the brain of mice, does the epigenetic clock of other parts of the body age as well. In other words, are the clocks all coupled so tightly that aging in one organ affects the others?

If the answer is "yes", and if it also works in reverse, so that de-aging one organ somewhat de-ages the others (partially resets their clocks), then that would be a way to greatly slow aging! Basically, replace several organs with 3D-printed "young" copies; then, over time, all the other organs will become younger, too.

Perhaps, assuming that recent paper on HGH-induced age-reversal pans out, this is the cause: HGH caused the thymus to operate like when the person was young; which, in turn, caused the immune system to de-age (as measured by epigenetic clock).
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#82
starspawn0

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https://mobile.twitt...046160480722944

You are looking at the #future. A device that will soon look like small bandaid & measure 100s of biomarkers, telling you what’s best to eat & when to get to the doctor, pushing diseases & frailty off into the future. #health #OptimalHealth #tech #fitness


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#83
starspawn0

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From 2016: might be a way to protect DNA from reactive oxygen species:

https://www.newscien...ld-for-its-dna/

Given that DNA damage is claimed to be a major cause of aging (by David Sinclair), this might have life-extension effects.
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#84
starspawn0

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Researchers Identify Cells that Drive Human Skin Aging

https://discoverysed...man-skin-aging/

Just think:. Senolytics could be a way to keep people looking young, by virtually eliminating wrinkles and other signs of skin aging.

Three authors report that they are employees of Unilever and state, “although no products were tested, this work could potentially promote the use of anti-aging products and lead to financial gain for Unilever.”


That's an understatement!

#85
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Perhaps this should be considered medical news, but I have a future sci-tech angle on it:
 
https://spectrum.iee...work-heart-rats

Bionic Pacemaker Controlled by Neural Network Reverses Heart Failure in Rats

....

In a paper published this week in the Journal of Physiology, Paton and his colleagues describe a smarter pacemaker that puts natural variation back into a failing heart, helping it to work more efficiently.

The device reads the electrical signals generated by each breath, and paces the heart accordingly. In rats with heart failure, the device increased the amount of blood their hearts could pump by 20%, compared with monotonic pacemaking, according to the study.


Might work in people. Here's my future take: why not do this for other organs, too, like the kidneys and liver? e.g. the body has ways of estimating how much insulin it will need, but sometimes it guesses wrong. What if by using deep neural nets that take in sensory input, they can stimulate and inhibit organs to where they react more efficiently? I bet it's possible. ​

#86
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https://youtu.be/E-IaSS0bbGU

Nov 14, 2019
Investor and entrepreneur Peter Thiel delivers the 2019 Wriston Lecture.

---------------------------------------------------------

Peter Thiel is 52 years old. He looks 22 years old. 



#87
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Two articles:
 
Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice 
 
https://www.ncbi.nlm...les/PMC5295690/

Astaxanthin appears to significantly slow skin photo-aging.

It appears to have lots of good effects on the body. If you take enough of it, it will settle in your body fat and make you look redder, just like how shrimp turn red. Beta Carotene and Canthaxanthin will likewise darken you skin, as they settle into your fat; and are used skin tan pills. It takes weeks for your skin to return to normal.

There is some risk, however: take too much, and there is a slight increased risk of cancer; and too much Canthaxanthin can cause crystals to form in your retina, that impair vision. But this appears to be rare.

....

Olive oil superfood may protect the brain from age-related dementia

https://www.slashgea...entia-25601431/

Mouse study shows that extra virgin olive oil can reduce bad brain Tau deposits by half. Might also hold in humans. It's known that diet can significantly improve brain health and slow aging.

#88
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I've been taking Astaxanthin, over 16 mg per day. I've noticed some subtle effects, but I'm not sure it is due to that supplement -- could be due to changes in the season.

The two effects I have noticed:

* My skin has changed color a little. Yellow and also slightly pink -- I'd say the color change is more yellowish than pink. If I keep taking it, hopefully it will look more brownish, which would resemble a tan.

* My skin feels a little "tighter". Perhaps "a little more waxy" is a better descriptor. When I pinch my arm, the surface of the skin feels slightly more waxy, and doesn't stretch as much as usual; resists stretching, and skin feels "thicker". My face feels smoother.

I've read that Astaxanthin improves skin by keeping it from drying out. I can see that -- the ever so subtle waxy coating would probably keep water from escaping, and that will have the effect of making skin look younger. I've noticed when using sun-screen, the oil improves my skin.

....

Anyways, I will repeat that these beneficial effects may not be due to Astaxanthin; but if not, I don't know what else would cause them -- and I'm not imagining it.
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#89
Jessica

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Alzheimer’s Drugs Reverse Broader Aging

Brian Wang | December 13, 2019

 

In mouse models of Alzheimer’s disease, the drug candidates (CMS121 and J147) improve memory and slow the degeneration of brain cells. Researchers have shown how these compounds can also slow aging in healthy older mice, blocking the damage to brain cells that normally occurs during aging and restoring the levels of specific molecules to those seen in younger brains.

In the new research, Maher, Currais and their colleagues turned to a strain of mice that ages unusually fast. A subset of these mice was given CMS121 or J147 beginning at nine months old — the equivalent of late middle age in humans. After four months, the team tested the memory and behavior of the animals and analyzed genetic and molecular markers in their brains.

Not only did the animals given either of the drug candidates perform better on memory tests than mice that hadn’t received any treatment, but their brains showed differences at the cellular and molecular levels. In particular, expression of genes associated with the cell’s energy-generating structures called mitochondria was preserved by CMS121 and J147 with aging.

 

https://www.nextbigf...ader-aging.html


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#90
Jessica

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Oisin and OncoSenX Antiaging Extends Life 20% Life Extension in Old Mice and Human Clinical Trial Early 2020f

https://www.nextbigf...medium=facebook

Brian Wang | October 31, 2019
Screen-Shot-2019-10-31-at-3.50.48-PM-730

Oisin and its spinout OncoSenX completed antiaging trials using synolytics to extend the life of old mice by 20%. They will have human clinical trials starting in early 2020. They will apply it to people with solid tumors.

They use a lipid nanoparticle to deliver a DNA plasmid into sensescent (aka zombie) cells. The old cells are triggered to die and this boosts health and longevity.

At Ending Age-Related Diseases, John Lewis of Oisin Biotechnologies discussed senolytics, which are drugs that kill senescent cells. He explained the differences between healthy and senescent cells along with the senescence-associated secretory phenotype (SASP) responsible for systemic inflammation. He went into detail about senolytics and what his company looks for when creating them, including details about suicide genes and biomarkers of senescence. He also discussed issues with bringing these drugs to humans and suggested oncology as a possible method for bringing them to the clinic.

 

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#91
Jessica

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Combination Gene Therapy Progressing Against Aging
Brian Wang | December 30, 2019
Screen-Shot-2019-12-30-at-12.19.21-PM-73

George Church indicates Rejuvenate Bio is working toward combination gene therapy against 300+ human genes that effect aging.

There is also progress in super-resolution imaging of chromosomes and hyper-detailed tissue analysis.

They will be able to analyze the DNA in the chromosome without breaking it up and knowing the exact position of the DNA.

Screen-Shot-2019-12-30-at-12.21.18-PM.jp

Screen-Shot-2019-12-30-at-12.18.28-PM.jp

Screen-Shot-2019-12-30-at-12.24.03-PM.jp

Microscopic imaging beyond the diffraction limit to 12 nanometers.

Screen-Shot-2019-12-30-at-12.24.32-PM.jp

The exponential biotechnology is scaling to the tissue and organ scale. It will then reach the full organism level.

 

https://www.nextbigf...inst-aging.html


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