A Kurzweil fan pointed this out:
So, I have been wondering for a while now why the cadence of Ray's public appearances seems to have plummeted in the past several months, so this may well be a case of confirmation bias -- in fact, I hope this to be the case, as it gives me no pleasure to say this -- but it appears Ray may be developing early symptoms of Alzheimer's. Examples of what I mean:
45m43s: Stuttering, long pauses between sentences, repeating words, mixes up inflationary/deflationary etc. This is a common pattern throughout the whole talk, which is considerably slower paced than Ray's previous lectures.
58m30s: In discussing AlphaFold protein folding, Ray contemplates for a long time, then refers to it as "neural unfolding, which is a very important problem in biology. Each neuron puts out a linear sequence of amino acids." A very strange mistake to make.
1h3m26s: Pauses for ~7s for no apparent reason.
Et cetera, et cetera. Mind you, this is coming from someone who has seen literally hundreds of Kurzweil talks. Make of it what you will.