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What are the Potential Applications using CRISPR Gene Editing?

CRISPR Biotechnology

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8 replies to this topic

#1
karthikaqpt

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CRISPR” stands for Clustered Regularly Interspaced Short Palindromic Repeats, which are the hallmark of a bacterial defense system which forms the basis for the popular CRISPR-Cas9 genome editing technology.

 

Crispr/cas9 is basically a gene editing tool which enable us to insert or remove gene effectively.​

 

The CRISPR/Cas9 system has been used to achieve efficient genome editing in a variety of species and cell types, including human cell lines, bacteria, zebrafish, yeast, mouse, fruit fly, roundworm, rat, rabbit, common crops, pig, and monkey.

 

Applications:

 

1.Cure Diseases (Like HIV, Cancer, Malaria, Sickle Cell Anemia)

2.Using CRISPR to reverse retinitis pigmentosa and restore visual function

3.It helps to alleviate Depression

4.CRISPR successfully lowers Cholesterol in Mice

5.partially restores vision in blind animals

6.CRISPR stores a Movie into the DNA of Bacteria

 

Latest 10 Inventions Using CRISPR Gene Editing



#2
Sciencerocks

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1. Most people will be skinny

2. Increased intelligence

3. Perfect organs that don't have flaws

 

The list goes on and on



#3
funkervogt

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CRISPR has taken our gene editing abilities to new heights, but I think it's error rate is still too high for it to be used to make genetically engineered humans that are significantly better than average. We'll have to wait for whatever the successor to CRISPR is. 

 

If you want to imagine what is ultimately possible, consider what our most extraordinary humans are currently like, and imagine that being the future "average."

 

https://www.mitathle...a_yzye?view=bio

https://youtu.be/pI76CiwvPV4

https://en.wikipedia.../Cindy_Crawford

https://en.wikipedia...inklevoss_twins



#4
caltrek

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CRISPR Treatment Inserted Directly Into the Body for the First Time

 

https://www.nature.c...586-020-00655-8

 

Introduction:

 

(Nature) A person with a genetic condition that causes blindness has become the first to receive a CRISPR–Cas9 gene therapy administered directly into their body.

 

The treatment is part of a landmark clinical trial to test the ability of CRISPR–Cas9 gene-editing techniques to remove mutations that cause a rare condition called Leber’s congenital amaurosis 10 (LCA10). No treatment is currently available for the disease, which is a leading cause of blindness in childhood.

 

d41586-020-00655-8_17772480.jpgSuper-precise CRISPR tool enhanced by enzyme engineering

For the latest trial, the components of the gene-editing system – encoded in the genome of a virus — are injected directly into the eye, near photoreceptor cells. By contrast, previous CRISPR–Cas9 clinical trials have used the technique to edit the genomes of cells that have been removed from the body. The material is then infused back into the patient.

 

“It’s an exciting time,” says Mark Pennesi, a specialist in inherited retinal diseases at Oregon Health & Science University in Portland. Pennesi is collaborating with the pharmaceutical companies Editas Medicine of Cambridge, Massachusetts, and Allergan of Dublin to conduct the trial, which has been named BRILLIANCE.


The principles of justice define an appropriate path between dogmatism and intolerance on the one side, and a reductionism which regards religion and morality as mere preferences on the other.   - John Rawls


#5
Jessica

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I hope it can cure all diseases and stop aging. That is what I am hoping for.

 

Designer babies with 200 iq's, low heart disease, low cancer risk and super long life spans.



#6
Hyndal_Halcyon

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Artificial ecosystems. I'd say organisms, but they wouldn't last long without their own home. Preferably ones that could eat plastic and heavy metals as well as generate construction materials. Or at least creatures that utilize lasers.


As you can see, I'm a huge nerd who'd rather write about how we can become a Type V civilization instead of study for my final exams (gotta fix that).

But to put an end to this topic, might I say that the one and only greatest future achievement of humankind is when it finally becomes posthumankind.


#7
Poncho_Peanatus

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re-creation of ancient eco systems. If I could I would love to regenerate ancient flora from the Paleozoic and mesozoic



#8
caltrek

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CRISPR tool scales up to interrogate a huge line-up of viral suspects

 

https://www.nature.c...586-020-01447-w

 

Introduction:

(Nature) The current severe effects of the global pandemic of COVID-19 reveals our vulnerability to emerging infectious diseases1,2. It also highlights the need for tools to detect a broad range of disease-causing agents, both known and recently emerged, that could threaten public health. However, the genetic diversity of the potential perpetrators, which include viruses, bacteria, fungi and protozoa, presents a practical difficulty. Molecular methods that detect nucleic acids are uniquely suited to this task because such infectious agents contain DNA, RNA, or both, that enables their recognition and identification. Feasible surveillance methods for tracking emerging global infections must have broad detection capability, be suited to high-throughput use and have low cost per test. Writing in Nature, Ackerman et al.3 describe an attempt to meet these requirements using a diagnostic detection platform they have created, called CARMEN (combinatorial arrayed reactions for multiplexed evaluation of nucleic acids).

 

CARMEN is an extension of SHERLOCK, a diagnostic platform previously developed by some members of the same team4 that was built around the biotechnology tool CRISPR, which can be used to selectively edit nucleic acids. CRISPR is based on a bacterial defence system. Its use as a laboratory tool depends on a ‘guide’ RNA (also termed a CRISPR RNA) present in a complex with a Cas enzyme. If the guide RNA binds to a nucleic-acid target that is complementary to it in sequence, Cas is activated and cleaves the target.

 

Some Cas proteins cut target nucleic acids only at a specific site related to the guide sequence. However, Cas13 is different from other Cas proteins in that it digests only RNA and not DNA5, and exerts its RNA-cleaving activity on any nearby RNA that it encounters. This property can be used to generate a signal that indicates the presence of a sequence of interest.

 

This principle underlies SHERLOCK and CARMEN. A reporter RNA is cleaved in a non-sequence-specific manner by Cas13 if it is activated through recognition of a specific sequence. This cleavage generates a fluorescent signal by separating two components attached to the reporter RNA: a fluorescence quencher and a fluorescent molecule.


The principles of justice define an appropriate path between dogmatism and intolerance on the one side, and a reductionism which regards religion and morality as mere preferences on the other.   - John Rawls


#9
Zeitgeist123

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so guys, what are the future benefits of crispr?

 

will it reverse aging? increase our intelligence, enhance our beauty, increase our stamina? make us immune to cancer and other harmful bacterias and viruses? will it cure any psychiatric conditions? enhance our senses?


“Philosophy is a pretty toy if one indulges in it with moderation at the right time of life. But if one pursues it further than one should, it is absolute ruin." - Callicles to Socrates






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