In response to wjfox's status.
Potential predictions, particularly ones that aren't well-sourced due to not being widely considered:
Genetically-Modified Persons becomes a major social issue: I don't believe that the rich are going to be the only ones who will have access to GM tech. Rather, it will quickly become disseminated into the middle class. And that will cause a moral panic. Religious groups and anti-GMO groups will demand segregation against lower-class persons and pets with an excuse of them being 'unhealthy' or dangerous to the genetic stability of humanity, while wealthy gene-modded people will be demonized as unnatural (but as belonging to either the opposing political party or as part of class war narratives in general). In an underdeveloped country, there will be at least one GMP-based pogrom that will include people who are only accused of being genetically modified.
Entertainment industry is unrecognizable: The progression of media synthesis has rendered major media companies vastly reduced. This means it's possible for individuals and small groups to live in their own constructed realities and histories. Combining this with full-dive VR means full-fledged alternative realities. Getting a job in entertainment or news is more of a quaint hobby akin to being a human computer, and maintaining a career is seen as obsolete.
Most communication is telepathic: The rise of brain-computer interfaces will give rise to brain-to-brain communication, allowing humans to speak to each other in ways that are impossible today, including sending images, videos, memories, emotional states, and more. The precedent was set with the rise of digital communication and texting and as early as the 2030s "virtual telepathy" had become a widespread means of communication, and by 2070, verbal speech has become rare to the point some humans have gone their entire lives without speaking.
Entirety of Earth's surface has been mapped in detail: By 2100, there are no places on Earth that have not been extensively mapped and recorded by autonomous drones and some human expeditions. By the 21st century, the majority of land had been explored, but some of the most remote and inhospitable regions remained out of reach. However, even well into the century, only a tiny percentage of the seafloor had been mapped in detail. With the rise of autonomous robots and drones, this has changed. With this mapping, we've also discovered thousands of otherwise elusive species and even a scant few "cryptids".
Zero Population Facilities are active on the Moon: Starting some time in the mid-21st century, there are missions to send autonomous drones to the moon to rapidly build up colonies and industrial centers, creating places for humans to eventually inhabit ahead of time or entire mining facilities that will never contain a single human.
Just a few ideas. I wish there were more sources on these.