Aging & Longevity News and Discussions

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wjfox
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Ken_J
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That charles guy is a bit insufferable. He came in with the premise that he's getting to call BS on Flim Flam artists, and never even lets anyone talk about the points he brings up.

he's so hung up on the idea of doing things that any interventions have to use the bodies own means to change itself. He doesn't even seem to grasp that one doesn't have to change the beta cells in a type one diabetic to produce insulin again in order to help a type one diabetic to survive years and decades more than they would without medications and insulin injections.
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wjfox wrote: Wed May 11, 2022 8:32 am
Def will have to watch at a later time. At laaaast life extension tech is making its debut! :D
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wjfox wrote: Tue May 17, 2022 5:25 pm
While I admire those who live at long, I'm thinking it can't be fun as the same time, sitting on a wheelchair all day not being able to do much, let alone probably feeling pain everywhere. :?

If they still lived few decades from now and thanks to burgeoning anti-aging rejuvenations, we wouldn't be able to distinguish them from that of a person in their 70s or even younger.
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The secret to a longer lifespan? Gene regulation holds a clue
https://phys.org/news/2022-05-secret-lo ... -clue.html
by University of Rochester

Natural selection has produced mammals that age at dramatically different rates. Take, for example, naked mole rats and mice; the former can live up to 41 years, nearly ten times as long as similar-size rodents such as mice.

What accounts for longer lifespan? According to new research from biologists at the University of Rochester, a key piece of the puzzle lies in the mechanisms that regulate gene expression.

In a paper published in Cell Metabolism, the researchers, including Vera Gorbunova, the Doris Johns Cherry professor of biology and medicine; Andrei Seluanov, professor of biology and medicine; and Jinlong Lu, a postdoctoral research associate in Gorbunova's lab and the first author of the paper, investigated genes connected to lifespan. Their research uncovered specific characteristics of these genes and revealed that two regulatory systems controlling gene expression—circadian and pluripotency networks—are critical to longevity. The findings have implications both in understanding how longevity evolves and in providing new targets to combat aging and age-related diseases.
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Research may reveal why people can suddenly become frail in their 70s

Wed 1 Jun 2022 16.00 BST

A groundbreaking theory of ageing that explains why people can suddenly become frail after reaching their 70s has raised the prospect of new therapies for the decline and diseases of old age.

Researchers in Cambridge discovered a process that drives a “catastrophic” change in the composition of blood in older age, increasing the risk of blood cancers and anaemia, and impairing the effectiveness of white blood cells to fight infection.

The scientists believe similar changes occur in organs throughout the body, from the skin to the brain, potentially underpinning why people often age healthily for decades before experiencing a more rapid decline in their 70s and 80s.

“What’s exciting about this work is there may be a common set of processes at work,” said Dr Peter Campbell, a senior author on the study and head of the cancer, ageing and somatic mutation programme at the Sanger Institute in Cambridge. “Ultimately the goal would be slowing or intervening in the ageing process, but at the very least we see an option to use this to measure biological age.”

https://www.theguardian.com/science/202 ... -their-70s
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Study confirms benefit of supplements for slowing age-related macular degeneration
https://medicalxpress.com/news/2022-06- ... ation.html
by National Eye Institute
The Age-Related Eye Disease Studies (AREDS and AREDS2) established that dietary supplements can slow progression of age-related macular degeneration (AMD), the most common cause of blindness in older Americans. In a new report, scientists analyzed 10 years of AREDS2 data. They show that the AREDS2 formula, which substituted antioxidants lutein and zeaxanthin for beta-carotene, not only reduces risk of lung cancer due to beta-carotene, but is also more effective at reducing risk of AMD progression, compared to the original formula. A report on the study, funded by the National Institutes of Health, published in JAMA Ophthalmology.

"Because beta-carotene increased the risk of lung cancer for current smokers in two NIH-supported studies, our goal with AREDS2 was to create an equally effective supplement formula that could be used by anyone, whether or not they smoke," said Emily Chew, M.D., director of the Division of Epidemiology and Clinical Application at the National Eye Institute (NEI), and lead author of the study report. "This 10-year data confirms that not only is the new formula safer, it's actually better at slowing AMD progression."

AMD is a degenerative disease of the retina, the light-sensitive tissue at the back of the eye. Progressive death of retinal cells in the macula, the part of the retina that provides clear central vision, eventually leads to blindness. Treatment can slow or reverse vision loss; however, no cure for AMD exists.

The original AREDS study, launched in 1996, showed that a dietary supplement formulation (500 mg vitamin C, 400 international units vitamin E, 2 mg copper, 80 mg zinc, and 15 mg beta-carotene) could significantly slow the progression of AMD from moderate to late disease. However, two concurrent studies also revealed that people who smoked and took beta-carotene had a significantly higher risk of lung cancer than expected.

In AREDS2, begun in 2006, Chew and colleagues compared the beta-carotene formulation to one with 10 mg lutein and 2 mg zeaxanthin instead. Like beta-carotene, lutein and zeaxanthin are antioxidants with activity in the retina. The beta-carotene-containing formation was only given to participants who had never smoked or who had quit smoking.
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Saudi Arabia plans to spend $1 billion a year discovering treatments to slow aging

The oil kingdom fears that its population is aging at an accelerated rate and hopes to test drugs to reverse the problem. First up might be the diabetes drug metformin.

June 7, 2022

Anyone who has more money than they know what to do with eventually tries to cure aging. Google founder Larry Page has tried it. Jeff Bezos has tried it. Tech billionaires Larry Ellison and Peter Thiel have tried it.

Now the kingdom of Saudi Arabia, which has about as much money as all of them put together, is going to try it.

The Saudi royal family has started a not-for-profit organization called the Hevolution Foundation that plans to spend up to $1 billion a year of its oil wealth supporting basic research on the biology of aging and finding ways to extend the number of years people live in good health, a concept known as “health span.”

The sum, if the Saudis can spend it, could make the Gulf state the largest single sponsor of researchers attempting to understand the underlying causes of aging—and how it might be slowed down with drugs.

https://www.technologyreview.com/2022/0 ... metformin/
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I like posting and hoping that something comes true, but within my mind I honestly believe that anyone over 40 is probably fucked. Any anti-aging will likely take a few more decades(you know that extended life span of worms or rats story we like to post about?) only to give a few more years within the next couple of decades as any pill or shot will be regulated into the ground and any long term aging solution that we dream of to allow you to live for 200, 500 or even thousands of years will probably only come from designer babies or nano-bots repairing genes. The later is going to be regulated and probably banned into the ground for decades considering even a Chinese scientist can't even play around with the most simplest level of it. Such life spans will quite literally take a leader and a society that values eugenics and the mastery of what is possible with the human body. I am ok with such a leader as that is the only way for humans to truly become great! A leader of intelligence, a leader that wants better for his species and a leader that is willing to take the steps! We need a government and a president that is willing to support the scientist doing it. That is a fact.

I do have a little bit of faith in the kind that can add a few years here and there, but that isn't going to save you.
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weatheriscool wrote: Tue Jun 07, 2022 7:33 pm but within my mind I honestly believe that anyone over 40 is probably fucked.
Correction: anyone over 40 who isn't considering cryopreservation.
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weatheriscool wrote: Tue Jun 07, 2022 7:33 pm anyone over 40 is probably fucked.
:cry:
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wjfox wrote: Tue Jun 07, 2022 8:01 pm
weatheriscool wrote: Tue Jun 07, 2022 7:33 pm anyone over 40 is probably fucked.
:cry:
Honestly, I have a feeling the anti-aging field will accelerate a lot quicker than the progress we see today, thanks to future AI breakthroughs and surreptitious discoveries by unknown people.

So, I think it should be revised to "anyone who is over 60 is probably fucked, give or take a decade."
To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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There's surely some overlap, though.

I am 43 but don't smoke, rarely drink, get plenty of regular exercise, follow a strict and healthy diet, have now achieved the ideal weight/BMI, plus my grandparents lived to their late 80s/mid-90s so I may have inherited their good genes. I have a decent income, plenty of social connections, etc. and am generally happy (despite my somewhat curmudgeonly persona online). I take regular blood tests on Thriva, which show I'm optimal across a range of different health metrics. Also, without wishing to sound vain, I'm frequently told that I look 10 years younger than my chronological age.

Contrast that with a 43-year-old slob, who has the appearance of a 60-year-old, who smokes every day, drinks heavily, doesn't exercise much (if at all), eats junk food and high-sugar drinks all the time, whose parents died younger than the average lifespan, and who doesn't take an interest in longevity or health apps/fitness technology, works a minimum wage job, and has little or no social connections/mental stimulation beyond watching TV.

I also think we need to consider the impact of AI and computing technologies, as Raklian just alluded to. Health and medicine are becoming more and more digitised and we know that information technologies follow exponential trends. The impact of AI on cancer discoveries, for example, is already becoming noticeable with a number of "better-than-human" studies published in recent years. Apply these same tools to aging/longevity and within a relatively short time (20-30 years) we could see major progress in the field.

It's also worth mentioning that we don't need a complete cure for aging – Terry Grossman has described the series of "bridges" that might be possible stepping stones to longevity escape velocity (LEV).

I also doubt that treatments would be heavily regulated/restricted, as the coming demographic crisis will necessitate improved healthspans for society in order to maintain economic growth, as well as care for the elderly. If anything, aging treatments might eventually be free, like the Covid vaccines.

So, in summary, I honestly think I have a chance of reaching LEV, if I can maintain this current healthy lifestyle, if I can reach 85-90 or so, and if the world holds together in the face of multiple, converging crises. I'd give myself about a 40-50% chance.
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wjfox wrote: Tue Jun 07, 2022 8:31 pm
I also doubt that treatments would be heavily regulated/restricted, as the coming demographic crisis will necessitate improved healthspans for society in order to maintain economic growth, as well as care for the elderly. If anything, aging treatments might eventually be free, like the Covid vaccines.
Agreed, I think that most people, deep down, really want to live longer, healthier lives. It's weird how some just go "Death is not to be feared; it's natural; it's unavoidable etc etc" but if they had the chance would 100% get any anti-aging treatment they could get their hands on :lol:
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Anti-aging clues lurk in lysosomes, the recycling centers of the cell
https://phys.org/news/2022-06-anti-agin ... cling.html
by Molly Chiu, Baylor College of Medicine
Scientists at Baylor College of Medicine, the Howard Hughes Medical Institute (HHMI) and collaborating institutions report in the journal Nature Cell Biology that lysosomes in roundworms produce molecules that allow cells to 'talk' to one another about aging, coordinating the process across the entire organism.

For decades, biology students have learned that lysosomes—tiny sacs found within nearly all cells—had a singular task: to gobble up bits of foreign material and worn-out cell parts. The aim? To break them down for recycling. But that lesson might soon need revising.

Dr. Meng Wang, professor and Robert C. Fyfe Endowed Chair on Aging of Molecular and Human Genetics and an investigator at HHMI at Baylor, has spent the past seven years exploring the link between longevity and the signals lysosomes produce.

Longevity, it seems, runs deep in Wang's blood—her paternal and maternal grandmothers lived until ages 100 and 95, respectively. "Neither was ill, and why they died remains a mystery," she said. "It makes me feel like there's some secret to longevity, and if we can study this, maybe we can use the knowledge and apply it to everyone."

"Cells in different organs and tissues around the body send signals to one another constantly," said Wang, a member of Baylor's Dan L Duncan Comprehensive Cancer Center. "When we are young, everything is connected and communicating, but as we age, some of these connections are lost and function declines."
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Secrets of aging revealed in largest study on longevity, aging in reptiles and amphibians

by Pennsylvania State University
https://phys.org/news/2022-06-secrets-a ... evity.html
At 190 years old, Jonathan the Seychelles giant tortoise recently made news for being the "oldest living land animal in the world." Although, anecdotal evidence like this exists that some species of turtles and other ectotherms—or 'cold-blooded' animals—live a long time, evidence is spotty and mostly focused on animals living in zoos or a few individuals living in the wild. Now, an international team of 114 scientists, led by Penn State and Northeastern Illinois University, reports the most comprehensive study of aging and longevity to date comprising data collected in the wild from 107 populations of 77 species of reptiles and amphibians worldwide.

Among their many findings, which they report today in the journal Science, the researchers documented for the first time that turtles, crocodilians and salamanders have particularly low aging rates and extended lifespans for their sizes. The team also found that protective phenotypes, such as the hard shells of most turtle species, contribute to slower aging, and in some cases even 'negligible aging'—or lack of biological aging.
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weatheriscool wrote: Tue Jun 07, 2022 7:33 pm I like posting and hoping that something comes true, but within my mind I honestly believe that anyone over 40 is probably fucked.
Contrastingly my opinion is that the first person to live to 200 might have been born in the 1940s or 1950s.
And remember my friend, future events such as these will affect you in the future
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