Artificial wombs, cloning, IVF, and other reproductive technology

[Vakanai]

While clearly they aren't capable of it yet and officially would be opposed to it and even recently punished a doctor for just genetically editing babies, I believe that China will likely try and solve its population declining problem via cloning. I could be wrong about this, but it's a move I can see them taking sometime past 2040.

[weatheriscool]

And yet people doubt me when I say that these cock sucking republicans are a huge threat to progress in science and will be used to attack all progress? Wake up Elon, Wake up!

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[firestar464]

Here is an actual article on the subject:

https://www.newswise.com/articles/bar-i ... -testicles

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First atlas of the human ovary with cell-level resolution is a step toward artificial ovary
https://medicalxpress.com/news/2024-04- ... ution.html
by University of Michigan

A new "atlas" of the human ovary provides insights that could lead to treatments restoring ovarian hormone production and the ability to have biologically related children, according to University of Michigan engineers.

This deeper understanding of the ovary means researchers could potentially create artificial ovaries in the lab using tissues that were stored and frozen before exposure to toxic medical treatments such as chemotherapy and radiation.

Currently, surgeons can implant previously frozen ovarian tissue to temporarily restore hormone and egg production. However, this does not work for long because so few follicles—the structures that produce hormones and carry eggs—survive through reimplantation, the researchers say.

The new atlas reveals the factors that enable a follicle to mature, as most follicles wither away without releasing hormones or an egg. Using new tools that can identify what genes are being expressed at a single-cell level within a tissue, the team was able to home in on ovarian follicles that carry the immature precursors of eggs, known as oocytes.

[firestar464]

Dozens of Babies Have Been Born from Uterus Transplants

https://archive.ph/CwNvj

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Human embryo "pause button" could boost IVF success
By Michael Irving
October 03, 2024

https://newatlas.com/biology/human-embr ... f-success/
Scientists have discovered a kind of “pause button” in early human development. This biological mechanism has long been known in other mammals, but its discovery in humans could aid IVF procedures.

Some mammal species have an ability known as embryonic diapause, in which the development of an embryo can be paused for weeks or even months, keeping the blastocyst from implanting in the uterus. This means the animal can wait out food scarcities or unfavorable seasons, and restart the pregnancy when conditions improve, better ensuring the survival of mother and young.

Species of rodents, bears, badgers, kangaroos and deer, among others, can make use of this process naturally, while scientists have triggered it in experiments in many others. But one thing wasn’t clear – whether diapause was retained in humans, even if we’ve since lost the ability to use it.

[Tadasuke]

US officials are hinting that the first in-human trial could soon be underway

The groundwork is being laid for the first human trial of an artificial uterus, which could get the go-ahead from the US Food and Drug Administration (FDA) some time in 2024.

I sure hope this is really going to happen in 2024! It would be a significant step forward.

I have been talking about artificial machines for developing human babies (hopefully with some human enhancements) for the last 25 years. As soon as I learned that babies are parasites existing in their mother's bodies, I've been thinking that such repulsive, sickening, cruel and distasteful phenomena must end as soon as possible. It has baffled me how can anyone be fond of something like that. I'm in my 30s, and I still hate pregnancy.

From what I have read and listened in podcasts, it is entirely possible for artificial wombs for human embryos to be deployed by the 1st half of the 2030s and for human body replacement body parts to be mass produced (with patient's unique DNA) by the 2nd half of the 2020s. Both changes would make human lives better. Choice, not constrain!

[weatheriscool]

First baby conceived via breakthrough fertility tech born
By Paul McClure
December 17, 2024

https://newatlas.com/medical/fertility- ... rst-birth/
An innovative fertility technology using stem cells to help an embryo mature outside the body has resulted in the world’s first live human birth. Gameto, the company that developed the approach, says it’s faster, safer and more accessible than conventional IVF.

Since the birth of the world’s first ‘test tube baby’ in 1978, in vitro fertilization (IVF) has helped millions of people worldwide overcome fertility issues and become parents. But while the procedure is designed to deliver a bundle – or bundles – of joy into the world, it’s not without some downsides.

A new fertility technique developed by Gameto, a female-led biotech company dedicated to advancing women’s reproductive health, provides an alternative to traditional IVF and, the company says, it has fewer drawbacks. What’s more, the first live human baby conceived by the technique - which is called Fertilo - was recently born.

“We are delighted to celebrate the world’s first live birth conceived using Fertilo,” said Dr Dina Radenkovic, Gameto’s CEO and co-founder. “By overcoming the major challenges of conventional IVF, such as long treatment cycles, significant side effects, and the emotional and physical strain, Fertilo provides a potentially faster, safer, and more accessible solution for families. This milestone marks a turning point in reproductive health and highlights the first application of iPSC [induced pluripotent stem cell] technology in IVF and the immense potential of our technology.”

[weatheriscool]

Explainable AI techniques reveal ideal follicle sizes for successful IVF treatments
https://medicalxpress.com/news/2025-01- ... licle.html
by Imperial College London

During IVF treatment, doctors use ultrasound scans to monitor the size of follicles—small sacs in the ovaries containing eggs—to decide when to give a hormone injection known as the "trigger" to prepare the eggs for collection and ensure that they are ready to be fertilized with sperm to create embryos.

The timing of the trigger is a key decision, as it works less effectively if the follicles are too small or too large at the time of administration. After the eggs are collected and fertilized by sperm, an embryo is then selected and implanted into the womb to hopefully lead to pregnancy.

Researchers used "Explainable AI" techniques—a type of AI that allows humans to understand how it works—to analyze retrospective data on more than 19,000 patients who had completed IVF treatment. They explored which follicle sizes were associated with improved rates of retrieving mature eggs to result in babies being born.

[wjfox]

'A little miracle': First baby born in UK to woman with transplanted womb

7 April 2025

A "miracle" baby girl has become the first child in the UK to be born to a mother using a donated womb.

The baby's mum, Grace Davidson, 36, was born without a functioning uterus, and received her sister's womb in 2023 – in what was then the UK's only successful womb transplant.

Two years after that pioneering operation, Grace gave birth to her first child in February. She and her husband, Angus, 37, have named their daughter Amy after Grace's sister, who donated her womb.

Holding baby Amy - who weighed just over two kilos (four and a half pounds) - for the first time was "incredible" and "surreal", new mum Grace says.

"It was quite overwhelming because we'd never really let ourselves imagine what it would be like for her to be here," she says. "It was really wonderful."

https://www.bbc.co.uk/news/articles/c78jd517z87o

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Newly discovered ovulation regulator holds promise for managing infertility
https://medicalxpress.com/news/2025-06- ... ility.html
by Krisy Gashler, Cornell University

Cornell researchers have discovered a new cell signaling pathway involved in ovulation, a potential target for future research on infertility, contraception and ovarian disease.

Semaphorin proteins have been shown to be critical players in the vascular, nervous and immune systems, and in cancer development. Semaphorin 3E (Sema3E) also plays a role in facilitating ovulation in mice, according to a paper published in Advanced Science and co-authored by 10 Cornell researchers and two colleagues from Baylor College of Medicine. The first author is Hanxue Zhang, postdoctoral associate in the lab of Yi Athena Ren, assistant professor of animal science in the College of Agriculture and Life Sciences.

"Female reproductive tissues, such as the uterus and the ovary, are unique: No other tissue in adult life goes through a similar cycle of drastic construction and deconstruction—every month in women and every four days in mice," Ren said. "We wanted to understand how different types of cells in the ovary communicate and coordinate with each other to enable such changes under the control of reproductive hormones."

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Male birth control pill clears initial safety hurdle
https://medicalxpress.com/news/2025-07- ... urdle.html
by Justin Jackson, Phys.org

YourChoice Therapeutics, working with Quotient Sciences and Incyte, reports that single oral doses of the investigational non‑hormonal male contraceptive YCT‑529 up to 180 mg produced no clinically relevant safety issues in 16 healthy men.

Unintended pregnancies account for roughly half of conceptions worldwide, with men relying almost exclusively on condoms (13% failure rate) or vasectomy for prevention. Earlier small-molecule approaches such as WIN 18,446 and gossypol curtailed sperm production but triggered alcohol-related reactions or hypokalemia, ending research for decades.

In the study, "Safety and pharmacokinetics of the nonhormonal male contraceptive YCT-529," published in Communications Medicine, researchers conducted a randomized, double-blind, placebo-controlled single-ascending-dose trial to assess safety, tolerability, pharmacokinetics, and exploratory pharmacodynamics.

Sixteen vasectomized men aged 32–59 years (BMI 21.9–31.1 kg/m2) received YCT‑529 (n=12) or placebo (n=4) at the Quotient Sciences Phase 1 unit in the UK. Capsule-form YCT-529 or placebo was administered with water. Continuous Holter ECGs, serial blood draws, psychosexual diaries, and inflammatory biomarker panels were collected for up to 336 hours post-dose.

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[weatheriscool]

This is wonderful news! I'd like to see this developed into a cyborg wife one day that can have you child and help you with raising it. A man should be able to have kids! This is so wonderful.

[zzz]

Posted it again award