Aging & Longevity News and Discussions

[raklian]

[firestar464]

Man the dude himself noticed us

[wjfox]

[Tadasuke]

Researchers tracked data on students in grades 9 through 12 from 1991 through to 2021. They report a 16-fold decline in daily cigarette use (16.33x to be exact) — from 9.8% of teens saying they smoked daily in 1991 to 0.6% by 2021.

"Occasional" (at least 1 cigarette over the past month) smoking dropped from 27% of teens to 3.8% by 2021, a sevenfold decline (7.1x to be exact). That's a very significant drop in 30 years, but the question is, whether they replaced smoking with vaping and what will be long term effect of vaping. There are now significantly more vape stores than there were in 2014.

Even though reductions in smoking among young people is certainly a welcome news, it may take time to show up in improved life spans. For lung and other cancers, reductions do not even begin to emerge for years after quitting, and even after 10 years, remain midway between the continuing smoker and lifelong nonsmoker.

source article: https://www.healthday.com/health-news/c ... ly-smokers

[raklian]

Pretty interesting.

[weatheriscool]

Diet Control of Isoleucine Increases Healthspan and Lifespan By Up to 33% in Mice
March 23, 2024 by Brian Wang
https://www.nextbigfuture.com/2024/03/d ... -mice.html

Low-protein diets promote health and longevity in diverse species. Restriction of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of these benefits in young C57BL/6J mice. Restriction of dietary isoleucine (IleR) is sufficient to promote metabolic health and is required for many benefits of a low-protein diet in C57BL/6J males. Here, we test the hypothesis that IleR will promote healthy aging in genetically heterogeneous adult UM-HET3 mice. We find that IleR improves metabolic health in young and old HET3 mice, promoting leanness and glycemic control in both sexes, and reprograms hepatic metabolism in a sex-specific manner. IleR reduces frailty and extends the lifespan of male and female mice, but to a greater degree in males. Our results demonstrate that IleR increases healthspan and longevity in genetically diverse mice and suggests that IleR, or pharmaceuticals that mimic this effect, may have potential as a geroprotective intervention.

• Isoleucine restriction (IleR) improves metabolic health in both sexes
• IleR reprograms hepatic metabolism in a sex- and age-dependent manner
• IleR reduces frailty and increases lifespan, with stronger effects on male lifespan
• Amino acid restriction begun at 6 months extends healthspan but not lifespan

[raklian]

Article in question - https://www.lifespan.io/news/restoring- ... 7cd5e6d17c

[wjfox]

I hope he is right.

But at the same time, I will be devastated to lose my parents (both aged 75).

[Tadasuke]

I've been believing in LEV since the year 2000, I came up with this concept independently, then heard about it in TV and then read about it, what made me feel validated in some way. Other people however have been ridiculing me simply for rarely mentioning the possibility of radical life extension (not everyone though, some people like it). It has affected me. I used to think, that ordinary people would be much more open to radical longevity and transhumanism, as for me, these were the obvious choices for all humanity. Seems like people are gradually, slowly opening up to this though. I've been persuading some people to donate to the Methuselah Foundation and to the SENS Foundation with unfortunately no avail.

Trendlines made by large institutions are often wrong. For example, trendlines for photovoltaics or electric mobility. I saw "official" trendlines for PVs, EVs and orbital rocket launches putting current prices or prevalence 30 extra years into the future. Truly pessimistic. I also know that some people in the West think that life expectancy for example in India is 20 years lower than it really is. Or that life expectancy in my country is 8 years lower than it really is. Or that only 50% of people in the world have access to electricity, when in reality it's 90% (maybe possibly even 91% in 2024). Tony Seba's predictions are closer to reality than the pessimists predictions.

People are almost always wrong about the future. Very rarely there is an accurate prediction.

[erowind]

.

[caltrek]

Calorie Restriction Study Reveals Complexities in How Diet Impacts Aging
April 17, 2024

Introduction:

(Eurekalert) UNIVERSITY PARK, Pa. — Penn State researchers may have uncovered another layer of complexity in the mystery of how diet impacts aging. A new study led by researchers in the Penn State College of Health and Human Development examined how a person’s telomeres — sections of genetic bases that function like protective caps at the ends of chromosomes — were affected by caloric restriction.

The team published their results in Aging Cell. Analyzing data from a two-year study of caloric restriction in humans, the researchers found that people who restricted their calories lost telomeres at different rates than the control group — even though both groups ended the study with telomeres of roughly the same length. Restricting calories by 20% to 60% has been shown to promote longer life in many animals, according to previous research.

Over the course of human life, every time a person’s cells replicate, some telomeres are lost when chromosomes are copied to the new cell. When this happens, the overall length of the cell’s telomeres becomes shorter. After cells replicate enough times, the protective cap of telomeres completely dissipates. Then, the genetic information in the chromosome can become damaged, preventing future reproduction or proper function of the cell. A cell with longer telomeres is functionally younger than a cell with short telomeres, meaning that two people with the same chronological age could have different biological ages depending on the length of their telomeres.

Read more of the Eurekalert article here: https://www.eurekalert.org/news-releases/1041676

caltrek: It is very frustrating when studies come up with such inconclusive results (see the rest of the article regarding how the study is inconclusive). Still, it is not surprising given the complexity of human biology.

For a technical presentation of the results of the study as published in Aging Cell: https://onlinelibrary.wiley.com/doi/10.1111/acel.14149

[Tadasuke]

When food is more expensive, it encourages (some people) eating less.

I just can't justify buying lots of food when I look at the prices. I' ve always found paying for a video game much more cost-effective than paying for food which disappears quickly and it seems like a waste. Also in an ecological sense. So much packaging for modern food!

[firestar464]

The smart thing is actually to buy more because of inflation imo

[weatheriscool]

Anti-aging biopharma company raises $40 million to begin human tests
By Paul McClure
April 24, 2024

“As people live longer, improving quality of life is paramount,” said Alex Morgan, a partner at Khosla Ventures, who chipped in to fund Rubedo’s first round of venture capital financing. “Rubedo is targeting senescent, or aging, cells that drive age-related disease. This first trial can bring us another step closer to achieving better healthspan.”

Senescent cells age and permanently stop dividing, but they don’t die. Over time, they accumulate in the tissues and release high levels of inflammatory chemicals and immune modulators that contribute to aging.

https://newatlas.com/medical/anti-aging ... al-trials/

[Tadasuke]

I've been saying since the 2000s, that what we want and need is not robotic nurses, caregivers or more human nursing, but making our bodies better, longer-lasting, less frail, more enduring (in whichever ways work best). We don't want to just be sickly mammals relying on robots to care for us all the time and if they for whatever reason stop, we die.

That's the direction worth pursuing. Healthcare instead of sickcare .

[raklian]

Turn Bio inks $300m epigenetic reprogramming deal with HanAll Biopharma

Licensing agreement focuses on development of epigenetic reprogramming treatments for age-related eye and ear conditions.

https://longevity.technology/news/turn- ... biopharma/

Longevity biotech Turn Biotechnologies today announced it has signed an exclusive global licensing agreement with Korean pharma giant HanAll Biopharma. The collaboration aims to develop multiple epigenetic reprogramming treatments for age-related eye and ear conditions, with the deal for the first product said to have a potential value of more than $300 million.

The agreement marks a significant expansion in the relationship between the two companies, building on HanAll’s 2022 investment in Turn Bio, which specializes in the development of treatments designed to repair tissue at a cellular level – restoring the youthful function of cells while maintaining their identity.

The next few years going to see more agreements and mergers of this nature. The longevity space is heating up.

[raklian]

Regenerating Damaged Heart Cells

https://news.feinberg.northwestern.edu/ ... art-cells/

Northwestern Medicine scientists have discovered a way to regenerate damaged heart muscle cells in mice, a development which may provide a new avenue for treating congenital heart defects in children and heart attack damage in adults, according to a study published in the Journal of Clinical Investigation.

“This is a first step to being able to address one of the most important questions in cardiology: How do we get heart cells to remember how to divide again so that we can repair hearts?” said Schumacker, who is also professor of Cell and Developmental Biology and of Medicine in the Division of Pulmonary and Critical Care.

The approach could also be used for adults who have suffered damage due to a heart attack, Schumacker said.

[wjfox]

Why do women outlive men? Cells that develop into sperm and eggs could give the answer

Thu 13 Jun 2024 05.00 BST

The enduring mystery of why women outlive men may come down to the smallest and the largest cells in the body: the sperm and eggs that are central to human reproduction.

Scientists in Japan have shown for the first time in vertebrates that cells that develop into eggs in females and sperm in males drive sex differences in lifespan, and that removing the cells leads to animals with the same life expectancy.

The experiments were performed on small, turquoise killifish, a freshwater species that reaches sexual maturity in a fortnight and lives for a matter of months, but the researchers suspect a similar biological mechanism could influence the lifespan gap in humans and other species too.

“The ageing process in killifish is similar to that in humans, so I don’t think humans are necessarily more complicated,” Prof Tohru Ishitani, the senior author on the study at Osaka University, said. “I think this research will be a stepping stone to understanding the control of ageing in humans.”

Globally, on average, women live about 5% longer than men. A multitude of factors contribute to the disparity, with young men more likely to die in accidents and through suicide, and women often leading healthier lifestyles. But the disparity is seen in other species, too: female apes and old world monkeys tend to live longer than their male counterparts.

https://www.theguardian.com/science/art ... the-answer



Credit: fishesoftexas/University of Texas, Austin

[weatheriscool]

Anti-aging molecule successfully restores multiple markers of youth
By Michael Franco
June 24, 2024

In pre-clinical trials, a small molecule effectively regrew neurons, reduced inflammation, and improved memory, speed, coordination, grip strength, and more. The finding could have a profound impact on aging and the diseases that accompany it.

In conducting the research, scientists at the University of Texas MD Anderson Cancer Center, turned their focus to telomerase reverse transcriptase (TERT), an enzyme that is known to help synthesize and extend telomeres, the protective caps at the ends of chromosomes that help cells divide. TERT levels are reduced as we age.

Without sufficient levels of TERT, when our telomeres shrink or get seriously modified, they can lead to a process that continually damages our DNA, which causes cells to release inflammatory compounds that can in turn lead to aging, tissue damage, and cancer.

https://newatlas.com/biology/tac-anti-aging-molecule/

[weatheriscool]

Study shows how liver damage from stress and aging might be reversible
https://medicalxpress.com/news/2024-06- ... sible.html
by Duke University Medical Center

While the liver is one of the body's most resilient organs, it is still vulnerable to the ravages of stress and aging, leading to disease, severe scarring and failure. A Duke Health research team now might have found a way to turn back time and restore the liver.

In experiments using mice and liver tissue from humans, the researchers identified how the aging process prompts certain liver cells to die off. They were then able to reverse the process in the animals with an investigational drug.

The finding, which appears in the journal Nature Aging, holds high promise for the millions of people who have some degree of liver damage—livers that are essentially old due to the metabolic stresses of high cholesterol, obesity, diabetes or other factors.

"Our study demonstrates that aging is at least partially reversible," said senior author Anna Mae Diehl, M.D., the Florence McAlister Distinguished Professor of Medicine at the Duke University School of Medicine. "You are never too old to get better."

Diehl and colleagues set out to understand how non-alcoholic liver disease develops into a severe condition called cirrhosis, in which scarring can lead to organ failure. Aging is a key risk factor for cirrhosis among those who have been diagnosed with non-alcoholic liver disease, known as metabolic dysfunction-associated steatotic liver disease, or MASLD. One in three adults worldwide have the disease.

Studying the livers of mice, the researchers identified a genetic signature distinct to old livers. Compared to young livers, the old organs had an abundance of genes that were activated to cause degeneration of hepatocytes, the main functioning cells of the liver.