boosting Notch signaling seems to also be something that can happen in small degrees in decreasing dietary cholesterol intake https://www.sciencedirect.com/science/a ... 071830683Xweatheriscool wrote: ↑Sat Feb 25, 2023 4:40 am Reversed With a Single Drug – “Incurable” Liver Disease May Be Curable
https://scitechdaily.com/reversed-with- ... e-curable/
By Sanford Burnham Prebys February 23, 2023
Human Body Liver.Pain DiseaseAlagille syndrome is a genetic disorder that affects the liver, heart, and other parts of the body. It is characterized by a reduction in the number of bile ducts within the liver, leading to bile accumulation and liver damage. The disease can also cause heart problems, including heart defects, and facial abnormalities.
A new study from Sanford Burnham Prebys has discovered a drug that can spur liver regeneration in patients with Alagille syndrome.
For the first time, research conducted by Associate Professor Duc Dong, Ph.D. has revealed that the detrimental effects of Alagille syndrome, a genetic disorder that has no cure, can be reversed using a single drug. The findings, published in the Proceedings of the National Academy of Sciences, have the potential to revolutionize the treatment approach for this rare condition, and could also shed light on more widespread diseases.
“Alagille syndrome is widely considered an incurable disease, but we believe we’re on the way to changing that,” says Dong, who is also the associate dean of admissions for Sanford Burnham Prebys’ graduate school. “We aim to advance this drug into clinical trials, and our results demonstrate its effectiveness for the first time.”
though it looks like too little and too much are both problematic and decreasing cholesterol had a much weaker effect than increasing it did. IF I understood the material correctly.