Stem Cells and Regenerative Medicine News and Discussions

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Stem Cells and Regenerative Medicine News and Discussions

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Stem-cell therapy

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. As of 2016, the only established therapy using stem cells is hematopoietic stem cell transplantation. This usually takes the form of a bone-marrow transplantation, but the cells can also be derived from umbilical cord blood. Research is underway to develop various sources for stem cells as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart disease.

Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial.

https://en.wikipedia.org/wiki/Stem-cell_therapy
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Stem Cell Ovaries Now Functional in Mice

The mice born in this experiment were fully healthy.

by Sedeer el-Showk
July 29, 2021

The entire ovarian niche of mice can now be generated in vitro from stem cells, as a study recently published in Science shows [1]. The researchers then carried out the remarkable feat of fertilizing the generated oocytes and growing healthy, fertile offspring from them. This advance offers an invaluable model for investigating oocyte development and may also have implications for assisted reproduction technologies.

Read more: https://www.lifespan.io/news/stem-cell- ... l-in-mice/


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Implant shows extreme promise for regenerating bone
https://medicalxpress.com/news/2021-08- ... -bone.html
by University of Nebraska-Lincoln
Its powers may not rival Wolverine's, but a regenerative implant engineered by researchers at the University of Nebraska Medical Center and University of Nebraska–Lincoln could help repair bone-deep damage following physical trauma, surgery or osteoporosis.

The team has developed a biodegradable, nanofiber-based implant, or scaffold, whose design could better regenerate bone by effectively guiding the migration of recuperative cells to the injury site. When implanted in rats with bone defects, the cylindrical scaffold promoted the regeneration of bone that was denser, more voluminous and more like the surrounding tissue than that achieved by many other state-of-the-art designs.

The implant spurred regeneration even without the aid of externally sourced stem cells or so-called growth factors, which help promote healing but can also introduce regulatory complications and side effects that range from inflammation to unchecked tissue formation.
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I'm just surprised there hasn't been more work into regeneration of enamel. Tooth decay is a massive issue in the world and stem cell research has never been as advanced as it is now. We know stem cells can do it; it's not a flawed practice. So what's the hold up?

This is the most recent news I can find about it:
Repairing Teeth using Stem Cells
And remember my friend, future events such as these will affect you in the future
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Good stuff! I sure hope more advances are done here because it saves lives.
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Intelligent Implants Raises $8.7 Million to Help You Grow a Spine
by Haje Jan Kamps
October 22, 2021

https://techcrunch.com/2021/10/22/intel ... eed-round/

Introduction:
(TechCrunch) Spinal surgery is not for the faint of heart at the best of times, but Intelligent Implants raised €7.5 million ($8.7 million) to make spinal surgery less of a pain in the backside. The company’s smart implants’ first application is in spinal fusion surgery — where two or more vertebrae are permanently connected to improve stability, correct a deformity or reduce pain. Globally, more than a million of these surgeries are performed, but they are typically seen as a last resort because of the risk of complications or continued pain after the operation.

Intelligent Implants uses wireless implantable electronics to stimulate, steer and monitor bone growth. The company points out that the current state-of-the-art post-operation management is potentially long-term dependence on physical therapy and/or painkillers. Intelligent Implants is wading into the market to add a more tech-forward solution to the mix.

The company’s smart, active implants aren’t the first devices in this category. You’ll be familiar with pacemakers and cochlear implants, which have been available since the 1950s and 1970s, respectively. Intelligent Implants’s innovation is in creating a solution that doesn’t require wires or batteries. The product is placed between vertebrae with the same standard surgical procedure as current non-active implants.

The implant is then powered externally through induction, much like how your phone might use a wireless charging pad. This creates an electric field that stimulates and guides bone growth.

“I don’t wish this surgery on anyone, but if you have to do it, we have to make sure that the outcomes are as good as they can be,” said John Zellmer, CEO of Intelligent Implants.
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Japan Team Carries Out World-first Spinal Cord Stem Cell Trial


https://www.courthousenews.com/japan-te ... ell-trial/

Introduction:
TOKYO (AFP via Courthouse News) — A Japanese university said Friday it has successfully transplanted stem cells into a patient with a spinal cord injury, in the first clinical trial of its kind.

There is currently no effective treatment for paralysis caused by serious spinal cord injuries, believed to affect more than 100,000 people in Japan alone.

Surgeons at Tokyo's Keio University want to study whether induced pluripotent stem (iPS) cells can be used to treat the injuries.

iPS cells are created by stimulating mature, already specialized, cells back into a juvenile state.

They can then be prompted to mature into different kinds of cells, with the Keio University study using iPS-derived cells of the neural stem.
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World First "Synthetic" Mouse Embryos Grown Without Need for Egg, Sperm, Or Womb
by Rachael Funnel
August 3, 2022

Introduction:
(IFL Science) Scientists have successfully grown mouse embryos using stem cells cultured in a petri dish. The novel method for embryonic development research meant they could create synthetic mouse embryo models without the need for a natural embryo formed from a fertilized egg and a womb.

Embryonic development research took a leap forward when the Weizmann Institute of Science in Rehovot, Israel, found a way to keep mouse embryos alive for several days. Ferris-wheel-like incubators that carefully spin liquid enabled the embryos to develop to a far greater age than ever before, growing to roughly the size of a grain of rice with a visibly beating heart.

Now, reported in the journal Cell, scientists have gone one step further in creating those embryos for development without the need for what’s generally considered to be the basic building blocks of mammalian life: an egg, sperm, and a womb to cook it all in.

Instead, scientists have found a way to use stem cells cultured in a petri dish that had been programmed into a naïve state. By getting the stem cells to their earliest stage, they can increase their potential for development, creating stem cells that have the capacity to become almost anything.
Conclusion:
“Our next challenge is to understand how stem cells know what to do – how they self-assemble into organs and find their way to their assigned spots inside an embryo,” (Professor Jacob) Hanna (of Weizmann’s Molecular Genetics Department) continued. “And because our system, unlike a womb, is transparent, it may prove useful for modeling birth and implantation defects of human embryos.”
Read more here: https://www.iflscience.com/mouse-embry ... omb-64734 and here: https://www.iflscience.com/a-rotating- ... ays-59224
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World-first stem cell therapy trial treats spina bifida before birth
By Michael Irving
October 06, 2022
https://newatlas.com/medical/stem-cell- ... cal-trial/
In a world-first clinical trial, three babies have been born after receiving stem cell treatment for spina bifida. The treatment involves administering a stem cell patch to the fetus’ spine while still developing in the womb, and early results are promising one year on.

Spina bifida is a birth defect in which the spine fails to develop properly, which can lead to weakness or paralysis of the lower limbs, cognitive issues, and urinary and bowel dysfunction. While there’s no cure, post-birth surgery can improve the symptoms in some cases.

But a new clinical trial aims to intervene earlier. Because signs of spina bifida can appear very early on in the pregnancy, there’s time to treat it while the fetus is still developing, potentially improving the outcomes. That was the goal of the Cellular Therapy for In Utero Repair of Myelomeningocele (CuRe) trial, conducted at UC Davis Health.

Patients enrolled in the trial undergo surgery midway through pregnancy, where a patch containing mesenchymal stem cells is carefully applied to the affected area of the fetus’ spine in utero. Previous studies in sheep and dogs with spina bifida have shown that the technique can prevent paralysis, helping these young animals walk without noticeable disability.
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Baby's life 'probably saved' by umbilical stem cells

9 hours ago

A heart surgeon says he "probably saved the life" of a baby by carrying out a "world-first" operation using stem cells from placentas.

Professor Massimo Caputo from the Bristol Heart Institute used pioneering stem cell "scaffolding" to correct baby Finley's heart defect.

He hopes to develop the technology so children born with congenital cardiac disease won't need as many operations.

[...]

The so-called "allogeneic" cells were grown by scientists at the Royal Free Hospital in London, and millions of them were injected into Finley's heart muscle.

Allogeneic cells have the ability to grow into tissue that is not rejected and in Finley's case, have regenerated damaged heart muscle.

https://www.bbc.co.uk/news/uk-england-bristol-63946248


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