Aging & Longevity News and Discussions

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raklian
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To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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The Green Mediterranean / High Polyphenols Diet Promotes Dramatic Proximal Aortic De-stiffening, Twice as Much as the Healthy Mediterranean Diet


Introduction:
(Eurekalert) BEER-SHEVA, Israel, April 17, 2023 – The green Mediterranean – high polyphenols diet substantially regresses proximal aortic stiffness (PAS), a marker of vascular aging and increased cardiovascular risk. The green Mediterranean diet was pitted against the healthy Mediterranean diet and a healthy guideline-recommended control diet in the DIRECT PLUS, a large-scale clinical intervention trial. Researchers found that the green Mediterranean diet regressed proximal aortic stiffness by 15%, the Mediterranean diet by 7.3%, and the healthy dietary guideline-directed diet by 4.8%.

The study was recently published in the top ranked journal in the field of Cardiology, JACC (Journal of the American College of Cardiology). This is the first time that scientists have presented a powerful, potent effect of diet on the age-related proximal aortic stiffness.
DIRECT PLUS was a large-scale, long term clinical trial over 18 months among 300 participants, which used MRIs to measure aortic stiffness, the most accurate noninvasive measure.

Aortic stiffness is a measure of the elasticity of the blood vessel wall, and it occurs when the elastic fibers within the arterial wall (elastin) begin to fray due to mechanical stress. Proximal aortic stiffness (PAS) reflects the aortic stiffness from the ascending to the proximal-descending thoracic aorta; the section of the aorta, the largest artery in the body that carries oxygen-rich blood away from the heart. Proximal aortic stiffness is a distinct marker of vascular aging and an independent cardiovascular risk factor to predict morbidity and mortality.

The research was led by Prof. Iris Shai of Ben-Gurion University of the Negev, Israel, an adjunct Professor from the Harvard School of Public Health and an honorary professor at the University of Leipzig, Germany, along with her PHD student Dr. Gal Tsaban, a cardiologist from Soroka University Medical Center, and colleagues from Harvard and Leipzig Universities.

Read more here: https://www.eurekalert.org/news-releases/986376
(Healthline)

What are polyphenols?

Polyphenols are a category of compounds naturally found in plant foods, such as fruits, vegetables, herbs, spices, tea, dark chocolate, and wine.

They can act as antioxidants, meaning they can neutralize harmful free radicals that would otherwise damage your cells and increase your risk of conditions like cancer, diabetes, and heart disease.

Polyphenols are also thought to reduce inflammation, which is thought to be the root cause of many chronic illnesses.

Types of polyphenols

More than 8,000 types of polyphenols have been identified. They can be further categorized into 4 main groups.
• Flavonoids…
• Phenolic acids...
• Polyphenolic amides...
• Other polyphenols...
Source and more detail: https://www.healthline.com/nutrition/p ... -they-are
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Possible ‘Steps’ to Revealing Super-agers
April 17, 2023

Introduction:
(Eurekalert) On the quest for the proverbial fountain of youth, scientists have long looked for evidence of super-agers—people whose brain ages slower than their body. Researchers at the Del Monte Institute for Neuroscience at the University of Rochester have found older adults whose brain performance improves when they combine a cognitive task with walking.

“Identifying super-agers will leverage what we understand about the brain and aging,” said Eleni Patelaki, a Biomedical Engineering PhD student at the University of Rochester Medical Center and first author of the paper out today in NeuroImage. “But this is difficult to do because, in this case, there was no external evidence of this ability, and people are unaware that their brain is working differently.”

Walking and doing exposes brain flexibility

Researchers had the participants complete the same cognitive task while sitting and while walking. The 37 men and women, ages 62 to 79, scored similarly while sitting. When the same group repeated the test while walking, researchers found some individuals improved their cognitive performance. Researchers used Mobile Brain/Body Imaging (MoBI) to observe these changes and measure how the brain responded to the dual task. “We think this brain activity might constitute signatures of ‘super-aging,” said Patelaki. “We were able to find seven people, and now that we know where and how to look in the brain to find these super-agers, we can find more.”

The participants whose cognition improved while walking showed that their brain was able to adapt to and improve at the task—it had flexible usage of certain frontal resources. But those same people lost their flexibility in using the rest of their neural resources, similar to their peers who did not improve at the task while walking. This suggests that the brain’s ability to adapt or its flexibility in reallocating neural resources while walking might be an important factor in protecting cognition as we age.

Some young adult brains also improve

Previously, the same group of researchers in the Frederick J. and Marion A. Schindler Cognitive Neurophysiology Laboratory discovered that some young and healthy people also improve their performance on cognitive tasks while walking by changing the use of neural resources.

Read more here: https://www.eurekalert.org/news-releases/986389
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To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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Scientists slow aging by engineering longevity in cells
https://phys.org/news/2023-04-scientist ... cells.html
by University of California - San Diego
Human lifespan is related to the aging of our individual cells. Three years ago a group of University of California San Diego researchers deciphered essential mechanisms behind the aging process. After identifying two distinct directions that cells follow during aging, the researchers genetically manipulated these processes to extend the lifespan of cells.

As described in a new article published April 27, 2023, in Science, the team has now extended this research using synthetic biology to engineer a solution that keeps cells from reaching their normal levels of deterioration associated with aging.

Cells, including those of yeast, plants, animals and humans, all contain gene regulatory circuits that are responsible for many physiological functions, including aging. "These gene circuits can operate like our home electric circuits that control devices like appliances and automobiles," said Professor Nan Hao of the School of Biological Sciences' Department of Molecular Biology, the senior author of the study and co-director of UC San Diego's Synthetic Biology Institute.

However, the UC San Diego group uncovered that, under the control of a central gene regulatory circuit, cells don't necessarily age the same way. Imagine a car that ages either as the engine deteriorates or as the transmission wears out, but not both at the same time. The UC San Diego team envisioned a "smart aging process" that extends cellular longevity by cycling deterioration from one aging mechanism to another.

In the new study, the researchers genetically rewired the circuit that controls cell aging. From its normal role functioning like a toggle switch, they engineered a negative feedback loop to stall the aging process. The rewired circuit operates as a clock-like device, called a gene oscillator, that drives the cell to periodically switch between two detrimental "aged" states, avoiding prolonged commitment to either, and thereby slowing the cell's degeneration.

These advances resulted in a dramatically extended cellular lifespan, setting a new record for life extension through genetic and chemical interventions.
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weatheriscool wrote: Fri Apr 28, 2023 3:00 am Scientists slow aging by engineering longevity in cells
https://phys.org/news/2023-04-scientist ... cells.html
by University of California - San Diego
Human lifespan is related to the aging of our individual cells. Three years ago a group of University of California San Diego researchers deciphered essential mechanisms behind the aging process. After identifying two distinct directions that cells follow during aging, the researchers genetically manipulated these processes to extend the lifespan of cells.

As described in a new article published April 27, 2023, in Science, the team has now extended this research using synthetic biology to engineer a solution that keeps cells from reaching their normal levels of deterioration associated with aging.

Cells, including those of yeast, plants, animals and humans, all contain gene regulatory circuits that are responsible for many physiological functions, including aging. "These gene circuits can operate like our home electric circuits that control devices like appliances and automobiles," said Professor Nan Hao of the School of Biological Sciences' Department of Molecular Biology, the senior author of the study and co-director of UC San Diego's Synthetic Biology Institute.

However, the UC San Diego group uncovered that, under the control of a central gene regulatory circuit, cells don't necessarily age the same way. Imagine a car that ages either as the engine deteriorates or as the transmission wears out, but not both at the same time. The UC San Diego team envisioned a "smart aging process" that extends cellular longevity by cycling deterioration from one aging mechanism to another.

In the new study, the researchers genetically rewired the circuit that controls cell aging. From its normal role functioning like a toggle switch, they engineered a negative feedback loop to stall the aging process. The rewired circuit operates as a clock-like device, called a gene oscillator, that drives the cell to periodically switch between two detrimental "aged" states, avoiding prolonged commitment to either, and thereby slowing the cell's degeneration.

These advances resulted in a dramatically extended cellular lifespan, setting a new record for life extension through genetic and chemical interventions.
Aw yeah! :D
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Researchers discover Chinmo, 'the youth gene'
https://phys.org/news/2023-05-chinmo-youth-gene.html
by Institute for Research in Biomedicine (IRB Barcelona)
A new study published on eLife and led by the Institute for Evolutionary Biology (IBE, CSIC-UPF) and the IRB Barcelona, has revealed that the Chinmo gene is responsible for establishing the juvenile stage in insects. It also confirms that the Br-C and E93 genes play a regulatory role in insect maturity. These genes, which are also present in humans, act as a promoter and as a suppressor, respectively, of cancerous processes.

The results of the research, which was carried out with the fruit fly Drosophila melanogaster and the cockroach Blatella germanica, reveal that these genes have been conserved throughout the evolution of insects. Therefore, it is believed that they could play a key role in the evolution of metamorphosis.
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Update from Aubrey de Grey -

To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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