Aging & Longevity News and Discussions

[weatheriscool]

1 in 25 carries a genotype that is associated with a shortened lifespan, according to scientists
https://medicalxpress.com/news/2023-11- ... tists.html
by deCODE genetics

Scientists at deCODE genetics have published a study on actionable genotypes detected in the Icelandic population and their association with lifespan. The results of this study are among the things that have motivated the government of Iceland to announce a nationwide effort in precision medicine.

As the delivery of precision medicine to a population requires considerable amount of data on genomics, transcriptomics and proteomics of the population, Icelanders are currently exceptionally well suited for this effort because they hold an unprecedented amount of such data.

[weatheriscool]

New drug-like molecule extends lifespan, ameliorates pathology in worms and boosts function in mammalian muscle cells
https://medicalxpress.com/news/2023-11- ... ology.html
by Buck Institute for Research on Aging

Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process.

Researchers at the Buck Institute have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is a natural compound that extended lifespan in C. elegans, ameliorated pathology in neurodegenerative disease models of C. elegans, and improved mitochondrial function in mouse muscle cells. Results are published in the November 13, 2023, edition of Nature Aging.

[raklian]

It may be possible to quantify our healthspan, which is defined as the part of a person’s life during which they are generally in good health.

[raklian]

FYI - OSKM (which stands for transcription factors: Oct4, Sox2, Klf4, and c-Myc) reprogramming has garnered attention due to its potential in reversing cellular aging. As cells age, they accumulate damage and lose their functionality. Reprogramming can potentially reset some of this age-related damage, rejuvenating cells and restoring their function to a more youthful state.

[Tadasuke]

Still too optimistic on the timeline, but he is correct about things generally moving in the right direction:


I found this interesting. Not crazy, just slightly too optimistic. He says Longevity Escape Velocity 2029 if you are diligent. Probably not far from the truth.

[wjfox]

He says Longevity Escape Velocity 2029 if you are diligent.

For mice, worms, and fruit flies? Very possible. Likely, even!

Macaques and other primates? Great progress will be achieved, but I don't think they'll be quite there by 2029. Possibly 2030s.

Humans? In six years? Sorry, but that just isn't going to happen. I mean... it might be partially possible to reverse aging if you're a multi-millionaire, able to devote a chunk of your wealth to the absolute bleeding-edge, state-of-the-art, experimental treatments (e.g. involving blood transfusions, banks of stem cells, or whatever) and are prepared to follow an intense regime of diet/exercise/lifestyle changes that require most of your free time. So if you're in a position to do that (and perhaps Kurzweil is), then good luck. But for 99.9% of us, that isn't possible, and won't be possible for decades – until we've gained a more comprehensive picture of human biology, Phase 4 trials are passed, and treatments are competitive enough to be low cost.

[Tadasuke]

If Longevity Escape Velocity is more or less reached by 2050, then Kurzweil is not far off. Most people people probably think that such a feat will take hundreds of years or so.

Without taking care of aging, we won't live more than 130 years.

[raklian]

[caltrek]

Cutting Back on One Amino Acid Increases Lifespan of Middle-Aged Mice Up to 33%
by Less Cockerill
November 27, 2023

Introduction:

(Science Alert) A new study in mice found limited intakes of one particular essential amino acid slowed the impacts of ageing and even lengthened their lifespan.

Scientists are now wondering if these findings could help people improve their longevity and quality of life.

Isoleucine is one of three branched-chain amino acids we use to build proteins in our bodies. It is essential for our survival, but since our cells can't produce it from scratch, we have to get it from sources like eggs, dairy, soy protein and meats.

But there can always be too much of a good thing. Earlier research using data from a 2016-2017 survey of Wisconsin residents found dietary isoleucine levels were linked with metabolic health and that people with higher BMIs were generally consuming much greater quantities of the amino acid.

"Different components of your diet have value and impact beyond their function as a calorie, and we've been digging in on one component that many people may be eating too much of," says metabolism researcher Dudley Lamming from the University of Wisconsin, US, who was involved in both studies.

Read more here: https://www.sciencealert.com/cutting-b ... up-to-33

[raklian]