Aging & Longevity News and Discussions

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raklian
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To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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raklian
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I wonder what the news they consider "big" is going to be. Hmm...

To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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caltrek
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We've Discovered a Subtle Genetic Imbalance That May Drive Aging
by Carly Cassella
December 17, 2022

Introduction:
(Science Alert) Scientists have found an extremely subtle twist in the genetics of aging cells, one that seems to make them increasingly less functional as time goes on.

Researchers from Northwestern University have revealed animals like mice, rats, killifish, and even humans show a gradual imbalance of long and short genes in virtually every cell in their body as they age.

The discovery suggests there aren't specific genes that control the aging process. Instead, old age seems to be governed by systems-level changes with complex effects. And this can impact thousands of different genes and their respective proteins.

For an individual gene, however, the changes are so tiny as to be insignificant. That's probably why they've slipped past our notice until now.
"We have been primarily focusing on a small number of genes, thinking that a few genes would explain disease," says Northwestern University data scientist Luís Amaral.
Read more here: https://www.sciencealert.com/weve-disc ... ive-aging


caltrek’s comment: This may be good news in that it could result in a better understanding of the aging process. It does underline the complexity of it all. What I call “magic pill” solutions may be very far off, if at all achievable.

What current wisdom seems to suggest, at least to a layman such as myself, is the importance of a balanced diet and plenty of exercise. Fad diets that are highly imbalanced should be avoided. Five-day fasting along the lines suggested in Valter Longo’s The Longevity Diet may also be of benefit.
Don't mourn, organize.

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raklian
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raklian wrote: Mon Dec 19, 2022 8:44 pm I wonder what the news they consider "big" is going to be. Hmm...

I guess this is the big news. Basically crowdfund anti-aging projects with cryptocurrencies.

https://longevity.angelprotocol.io/
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Classifying aging as a disease could speed FDA drug approvals

by Amy Baker, Opinion Contributor
12/21/22 7:30 AM ET

The Food and Drug Administration (FDA) considers aging to be a natural process. This makes it difficult to get FDA approval for drugs that seek to slow or reverse the biological process of aging. Instead, drugs intended to target aging must target a disease that often results from the aging process in order to demonstrate efficacy and gain approval.

But there is growing consensus and effort among scientists to convince the FDA that aging itself should be classified as a disease and an appropriate target for drug development.

This could be a major milestone for not just industry, but society. If the FDA is swayed, the resulting regulatory shift could mean approval of drugs or treatments that slow or reverse the aging process generally, before a patient develops disease.

Researchers who view aging as a medical condition aren’t referring only to the inevitable passage of time. Instead, they view aging as a process of deterioration of our structure and function at the cellular level; the hallmark characteristics of which are genomic instability and damage to our DNA.  

And the World Health Organization (WHO) supports this view – WHO describes the process of aging as “… the impact of the accumulation of a wide variety of molecular and cellular damage over time.”

https://thehill.com/opinion/healthcare/ ... approvals/
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caltrek
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Re: Aging & Longevity News and Discussions

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^^^Gee thanks, WJ. I just called attention to this article to my wife. I do such things via email so that she can read attached articles. I felt compelled to title the subject: "I Was Wrong and You Were Right."

:lol:

Must learn to shed old school thinking about this sort of thing. BTW, her argument was that people really do die from "aging."

Proximate cause versus final cause and all that. It gets complicated.
Don't mourn, organize.

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Re: Aging & Longevity News and Discussions

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Scientists uncover a novel cellular mechanism that regulates aging and fertility
https://phys.org/news/2022-12-scientist ... aging.html
Research at the Institute of Molecular Biology and Biotechnology (IMBB) of the Foundation for Research and Technology-Hellas (FORTH), published today in the journal Nature Aging, reveals a fundamental quality control mechanism that operates in cells to safeguard the integrity and function of the nucleus. By maintaining nuclear homeostasis, this molecular mechanism contributes critically to promote longevity and fertility.

IMBB researchers Dr. Margarita-Elena Papandreou and Dr. Georgios Konstantinidis, headed by Dr. Nektarios Tavernarakis (Professor at the Medical School, University of Crete, and Chairman of the Board at FORTH), discovered that recycling of nuclear and nucleolar components via autophagy delays aging of somatic cells, and sustains the immortality of germ cells, which are required for reproduction.

The nucleus is the central organelle of all eukaryotic cells that contains the genetic material (DNA), which determines cellular identity and function. During aging and in cancer cells, the ultrastructure of the nucleus is dramatically altered. Moreover, progressive and pronounced deterioration of the nuclear architecture is a common and conserved feature of progeria and numerous other disorders associated with aging.

In addition, progeroid syndromes (e.g., Hutchinson–Gilford, Werner, Bloom, and Cockayne syndromes, among others), and aging itself, are accompanied by pronounced enlargement of the nucleolus—the largest well-defined structure within the nucleus—serving as the site for generating components of the ribosome, which is the protein synthesis machine of the cell. Notably, small nucleolar size has been associated with longevity and life-extending interventions. However, the molecular and cellular mechanisms that bring about these changes have remained obscure. It is also unclear whether such alterations are simply a corollary of the aging process and age-related pathologies, or have a causative role in progeria and senescent decline.
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raklian
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raklian wrote: Sat Dec 17, 2022 4:11 pm
To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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raklian
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:o

To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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raklian
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To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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