Aging & Longevity News and Discussions

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caltrek
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Just this week another study came out confirming the benefit of one sub-group of WFPB foods in avoiding diabetes:

Purple Vegetables and Tubers Have Antidiabetic Properties
February 15, 2023

Introduction:
(EurekAlert) The red, purple and blue pigments in fruits, vegetables, and tubers called anthocyanins can reduce the risk of diabetes by affecting energy metabolism, gut microbiota, and inflammation. A new review article comparing the research results in the topic shows that the beneficial effect of anthocyanins on type 2 diabetes is increased if the anthocyanin is acylated, meaning that an acyl group is added to the sugar moieties of anthocyanin.

A great amount of acylated anthocyanins can be found in purple potatoes, purple sweet potatoes, radishes, purple carrots and red cabbages, whereas bilberries and mulberries contain mostly nonacylated anthocyanins. Acylated anthocyanins are poorly absorbed in digestion, but they have probiotic properties and reduce the risk of diabetes more efficiently than nonacylated anthocyanins.

“The studies have shown that, in addition to changing physical and chemical properties, the acylation affects how the anthocyanins are absorbed and metabolised,” says Postdoctoral Researcher Kang Chen at Food Sciences Unit, University of Turku, Finland.

The acylated anthocyanins are more effective antioxidants than the nonacylated anthocyanins, and they can also improve the intestinal barrier that enables the absorption of necessary nutrients. Furthermore, the acylated anthocyanins maintain gut microbiota homeostasis , suppress pro-inflammatory pathways, and modulate glucose and lipid metabolisms.

“The plant's genotype defines what kind of anthocyanins they produce. In general, purple vegetables contain many acylated anthocyanins. Also, purple potatoes, especially the Finnish variety called ‘Synkeä Sakari’, is abundant in acylated anthocyanins,” says Chen.
Read more here: https://www.eurekalert.org/news-releases/979805
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caltrek
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While the article below does not make clear the benefits of a WFPB diet, it does point to the rejection of the Western Diet as beneficial:

Community Co-design Model Targets Indigenous Diet and Diabetes
February 15, 2023

Introduction:
(EurekAlert) Effective targeting of diabetes and metabolic syndrome in Australian Indigenous people requires remission strategies that are co-designed by Indigenous communities, according to a team of Flinders University researchers.

An article published in Nature Medicine journal identifies a project in South Australia’s Coorong region being led by Flinders University that takes a fresh approach through involving Ngarrindjeri leaders with clinicians trained in Eurocentric-based medicine to help tackle diabetes remission within its local community.
Further Extract:
Ketogenic eating works by restricting carbohydrate intake, so the body uses fat as the principal energy source rather than carbohydrate.

“A low-carbohydrate ketogenic eating plan appears similar to that of pre-colonisation eating patterns for Australian Indigenous people, so the uptake and maintenance of a ketogenic diet aligns with Indigenous knowledges,” says Associate Professor Ryder.

“A critical aspect to targeting diabetes and metabolic syndrome remission within Australian Indigenous communities is through centralising Indigenous knowledges and methodologies which have passed through generations and continue to evolve.”
Read more here: https://www.eurekalert.org/news-releases/979793
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Here is reported the results of a diet-based approach combined with exercise in addressing liver disease. It should be noted that Longo’s The Longevity Diet involves a five-day mimic fast to address the “risk factors such as diabetes, cancer, Alzheimer’s and heart disease.”

Alternate-day Fasting a Good Option for Patients with Fatty Liver Disease
February 14 , 2023

Introduction:
(EurekAlert) Nutrition researchers at the University of Illinois Chicago studied 80 people with nonalcoholic fatty liver disease and found that those who followed an alternate-day fasting diet and exercised were able to improve their health.

Publishing their findings in Cell Metabolism, the researchers report that over a period of three months people who exercised and alternated feast and fast days — eating without restriction one day and eating 500 calories or less the next — saw increased insulin sensitivity and decreased liver fat, weight and ALT, or alanine transaminase enzymes, which are markers for liver disease.

Nonalcoholic fatty liver disease is a buildup of fat and inflammation in patients who drink little to no alcohol. Approximately 65% of obese adults have the disease, and this condition is strongly related to the development of insulin resistance and Type 2 diabetes. If left unchecked, fatty liver disease can lead to more serious complications like cirrhosis or liver failure, but there are limited good drug options for treating the condition.
Study author Krista Varady called the findings “pretty amazing.”

“When we compared the results of our study groups, we saw clearly that the most improved patients were in the group that followed the alternate-day fasting diet and exercised five days a week,” said Varady, professor of nutrition at the College of Applied Health Sciences. “The people who only dieted or only exercised did not see the same improvements, which reinforces the importance of these two relatively inexpensive lifestyle modifications on overall health and on combating chronic diseases like fatty liver disease.”
Read more here: https://www.eurekalert.org/news-releases/979763

caltrek’s comment: If this study is correct, it shows that further refinement and tweaking of the approach suggested by Longo might have further beneficial effects on diabetes in particular.
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To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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This is pretty important for the anti-aging field, politically. This hints to the wider acceptance that aging reversal is a real possibility.

To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
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Global Longevity Conference Announcement

Introduction:
(Global Longevity Federation)

About Longevity Conference

Sciinov Group welcomes you to the “GLOBAL LONGEVITY FEDERATION (GLF 2023)” HYBRID EVENT during May 15-16, 2023 in Dubai, UAE. The GLF-2023 is scheduled in Hybrid Mode and will allow participants to join In-Person at Dubai or Virtually from Home or Office.

The GLF 2023 conference is the world’s leading and most longevity-focus conference. We gather the entire longevity ecosystem including longevity entrepreneurs, existing pharma and biotech companies, investors, researchers, and government organizations.

GLF-2023 creates a peer to peer learning environment focused on the business of longevity and the key areas of innovation needed to progress the longevity industry.

GLF-2023 is a premier interdisciplinary forum for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns, practical challenges encountered and the solutions adopted in the field of Aging and Geriatric Medicine.
The conference tries to put together an exciting scientific programme focused on longevity.
Read more here: https://longevityfederation.com/about.php
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caltrek
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Lower Frequency of Vegetable and Fruit Intake Linked to Higher Risk of Death Regardless of Chronic Kidney Disease (CKD) Status
February 26, 2023

Introduction:
(EurekAlert) Niigata, Japan - A new study of Japanese patients with and without CKD found that a lower frequency of vegetable and fruit intake was associated with a higher risk of death regardless of CKD status. Baseline serum potassium levels stratified by CKD stages were similar across the groups (according to the frequency of vegetable and fruit intake). The findings suggest that eating vegetables and fruits every day may not be associated with an increased level of serum potassium and that it may reduce rather than increase all-cause mortality in patients with CKD including those on HD, as has been observed for non-CKD individuals.

A higher fruit and vegetable intake is associated with a lower mortality risk in the general population. In contrast, patients with advanced CKD, especially those on HD, are generally discouraged from consuming high amounts of vegetables and fruits given the potential risk of hyperkalemia. Recent studies conducted in non-Asian countries suggest that a higher vegetable and fruit intake may be associated with lower mortality among adults with CKD, including those patients on HD and those who are not.

“We need to examine the association between vegetable and fruit intake and the risk of death in Japanese patients with CKD,” said Dr. Wakasugi, the corresponding author of the study. “The vegetable and fruit intake vary markedly across countries. Diets consumed by Asian populations are estimated to be higher in vegetables and fruits relative to diets consumed by other populations."
Read more here: https://www.eurekalert.org/news-releases/980919
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weatheriscool wrote: Fri Sep 16, 2022 5:30 am Can we live longer? Physicist makes discovery about telomeres
https://phys.org/news/2022-09-longer-ph ... meres.html
by Dagmar Aarts, Leiden University
With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery will help us understand aging and disease.

Physics is not the first scientific discipline that springs to mind at the mention of DNA. But John van Noort from the Leiden Institute of Physics (LION) is one of the scientists who found the new DNA structure. A biophysicist, he uses methods from physics for biological experiments. This also caught the attention of biologists from Nanyan Technological University in Singapore. They asked him to help study the DNA structure of telomeres. They have published the results in Nature.

String of beads

In every cell of our bodies are chromosomes that carry genes that determine our characteristics (what we look like, for instance). At the ends of these chromosomes are telomeres, which protect the chromosomes from damage. They're a bit like aglets, the plastic tips at the end of a shoelace.

More on telomeres:

New Study Reveals Yet Another Surprising Function of Telomeres
by David Nield
February 27, 2023

(Science Alert) We've known about telomeres for more than 80 years, but these tiny, protective structures at the end of the chromosomes keep revealing secrets to us, including the possibility of having surprising functions.

It turns out that these key biological cogs can produce proteins, something previously thought impossible due to their simplicity.

While it's not clear yet what these proteins might do, the fact that they exist at all is significant.

Telomeres carry our genetic information and play a crucial role in our bodies. As we age, telomeres lose their protective qualities, leading to cell death and damage. That structures so vital are operating in a way that we didn't previously know about means there are all kinds of potential possibilities.

The discovery was brought about through the identification of a molecule of RNA linked to amyotrophic lateral sclerosis (ALS). RNA helps to produce the proteins that drive the body's functions, and here researchers noted that this ALS-related RNA molecule was very similar to the one produced by telomeres.
https://www.sciencealert.com/new-telome ... and-cancer
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Vakanai
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weatheriscool wrote: Fri Jan 13, 2023 4:24 am I wish one of these scientist would do the right thing and start human trials on themselves. The benefits if they can pull off would probably be will worth it.
Endangering one's own health, career, and most importantly life is not "the right thing". I'd much rather the scientists and doctors continue doing the thorough testing on animals, cell cultures, ai models etc than risk their health. We should be as certain of the effects as possible before human testing. Safety should always trump our desire for speed.
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