by University of Texas M. D. Anderson Cancer Center
https://medicalxpress.com/news/2023-01- ... tumor.html
Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.
The outcomes, published today in Nature Medicine, were especially noteworthy in the subgroup of patients with synovial sarcoma, where afami-cel achieved an objective response rate of 44% compared to the overall response rate of 24% across all cancer types. Initial data from this trial were presented at the 2020 American Society of Clinical Oncology (ASCO) Annual Meeting.
According to principal investigator David S. Hong, M.D., professor of Investigational Cancer Therapeutics, these early results demonstrate a proof-of-concept for this novel cell therapy approach in solid tumors.
"These high response rates are significant because patients with synovial sarcoma really have very few options after high-dose chemotherapy with ifosfamide," Hong said. "The overall toxicity from afami-cel was manageable, and we saw evidence of early activity in other cancer types. These results suggest this is an approach with the potential to work in solid tumors where there are currently no approved cellular therapies."