Cancer News and Discussions

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wjfox
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Multi-cancer blood test shows real promise in NHS study

8 hours ago

A blood test for more than 50 types of cancer has shown real promise in a major NHS trial, researchers say.

The test correctly revealed two out of every three cancers among 5,000 people who had visited their GP with suspected symptoms, in England or Wales.

In 85% of those positive cases, it also pinpointed the original site of cancer.

The Galleri test looks for distinct changes in bits of genetic code that leak from different cancers. Spotting treatable cancer early can save lives.

The test remains very much a "work in progress", the researchers, from Oxford University, say, but could increase the number of cancers identified.

https://www.bbc.co.uk/news/health-65775159
weatheriscool
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For advanced, HER2-amplified bile duct cancers, antibody treatment trial shows promising results
https://medicalxpress.com/news/2023-06- ... ncers.html
by Memorial Sloan Kettering Cancer Center
Bile duct cancers are uncommon and aggressive types of gastrointestinal cancer. They include cholangiocarcinomas, which can form inside or outside of the liver, as well as cancers of the gallbladder, and are highly likely to cause serious disease or prove fatal.

Bile duct cancers affect the biliary tract, which consists of organs and ducts that make and store bile and release it into the small intestine. They are known as "silent" cancers, because there are usually no symptoms until they reach later stages. Surgery can be effective if bile duct cancer is caught early, but for most patients there are few good treatments.
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Breast cancer drug shown to reduce recurrence risk
https://medicalxpress.com/news/2023-06- ... rence.html
by Issam AHMED
A patient is pictured before a mammography at the Paoli-Calmette cancer institute in France in 2017.

Even when the disease is caught early, breast cancer recurrence is relatively commonplace—and for survivors, the prospect can be daunting.

A drug developed by Swiss pharmaceutical maker Novartis has now been shown to reduce this risk by a quarter in a large group of early-stage survivors, offering patients new hope.

Results from a clinical trial were presented Friday at the American Society of Clinical Oncology's (ASCO) annual meeting.

The study of ribociclib, which belongs to a newer class of medicines known as molecularly targeted therapies, was described as a "very important and practice-changing clinical trial," by ASCO expert Rita Nanda, who was not involved in the research.

The majority of the two million new breast cancers diagnosed globally are in the early phases of disease, defined as stages I through III.
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New ovarian cancer screening technique shows reduced false negatives compared to CA125 method
https://medicalxpress.com/news/2023-06- ... false.html
by Justin Jackson , Medical Xpress
Researchers at the Department of Obstetrics and Gynecology, Peking University Third Hospital in Beijing, China, have developed a new ovarian cancer screening technique. In a paper, "Profiling the metabolome of uterine fluid for early detection of ovarian cancer," published in Cell Reports Medicine, the research team details the markers and methods used to develop the test.

The researchers collected uterine fluid from 219 patients with various stages of ovarian cancer or benign gynecological diseases. No healthy patients were tested. The analysis of 1,213 metabolites was narrowed to just seven with significant associations with ovarian cancer.

In testing diagnostic ability, the study finds an overall 88% accuracy with their seven-marker method compared to 79% with the existing CA125 blood marker test.
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Many more women now beating early breast cancer

1 hour ago

Most women with early breast cancer now beat the disease thanks to huge improvements in treatments in recent years, a BMJ analysis has found.

Their risk of dying within five years of diagnosis is estimated to be below 3% - down from 14% in the 1990s.

Cancer Research UK says this offers "reassurance" to many women but warns more highly-trained staff are needed to meet rising demand.

A plan for NHS staffing in England has been repeatedly delayed.

Government ministers say this workforce strategy is due shortly.

https://www.bbc.co.uk/news/health-65882229
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https://www.msn.com/en-ca/health/medica ... kbar&ei=10

‘Breakthrough’ in the fight against deadly skin cancer
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Nanoparticles deliver small interfering RNA to slow multiple myeloma
https://phys.org/news/2023-06-nanoparti ... tiple.html
by Justin Jackson , Phys.org
Research led by the University of Pennsylvania, Philadelphia, has used siRNA-based silencing of protein cyclophilin A (CyPA) to reduce tumor burden and extend the lives of patients with multiple myeloma.

In the paper, "In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy," published in PNAS, the researchers detail a targeted nanoparticle platform to deliver nucleic acid therapeutics to bone marrow endothelial cells with a therapeutic payload.

Multiple myeloma (MM) is a blood cancer that occurs in the bone marrow and can form tumors outside bone marrow in the body's organs (extramedullary disease). MM is currently treatable but incurable, with inevitable relapse after treatment and typically short survival rates of 3 to 6 months for those with relapse as they build resistance to the treatments.
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New nanoparticle design may improve mRNA vaccine treatments for cancer
By Paul McClure
June 28, 2023
https://newatlas.com/medical/new-nanopa ... reatments/

Researchers have designed a new nanoparticle that was shown to more effectively deliver a cancer-fighting mRNA vaccine to mice. The study’s results may lead to the development of better vaccines to treat cancer and infectious diseases like COVID-19.

Cancer treatment has been revolutionalized by advances made, and continuing to be made, in the field of immunotherapy, the treatment of disease by activating or suppressing the body’s immune system. But each patient’s cancer tumor is unique, requiring treatments that target individual tumor-specific mutations. Using messenger RNA (mRNA) vaccines to deliver this treatment is a promising strategy.

Vaccines help prevent infection by preparing the body to fight pathogens such as bacteria or viruses. Most traditional vaccines contain a weakened or dead version of the bacteria or viruses to trigger an immune response. However, mRNA vaccines, such as the COVID-19 vaccine, work by introducing a piece of mRNA that corresponds to a protein found on the outside of a virus, causing the creation of antibodies and marking the virus for destruction. Once produced, antibodies remain in the body so it can respond quickly if the immune system is exposed to the pathogen again.

Now, a new study by researchers at Johns Hopkins Medicine may have found a way to improve the delivery of mRNA vaccines to treat infectious and non-infectious diseases.

When it comes to using mRNA vaccines to treat non-infectious diseases like cancer, the challenge has been to deliver materials to large numbers of dendritic cells, a special type of immune cells that teaches the immune system, particularly T cells, to seek and destroy cancer cells.
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weatheriscool
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About the only thing you can drink is coffee and water...Otherwise you're fucked.
sugar = being 500lb's
non-sugar subs = cancer and damaged dna.
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