COVID-19 News and Discussions

weatheriscool
Posts: 12727
Joined: Sun May 16, 2021 6:16 pm

Re: COVID-19 News and Discussions

Post by weatheriscool »

Novel monoclonal antibody therapy for SARS-CoV-2
https://medicalxpress.com/news/2022-10- ... -cov-.html
by Marla Paul, Northwestern University
An entirely new approach to monoclonal antibody therapy shows that targeting the more genetically stable internal protein of the SARS-CoV-2 virus rather than the surface spike protein can also clear SARS-CoV-2, reports a study from Northwestern Medicine and the University of Illinois at Chicago (UIC), published in the Journal of Clinical Investigation.

Some monoclonal antibody treatments have stopped working because the spike viral protein undergoes high rates of mutation, rendering some viral variants resistant to current antibody therapies. The novel approach could provide a new armament in treatments that could preserve effectiveness as the spike protein mutates.

This is the first time that therapeutic monoclonal antibodies have targeted an internal rather than a surface protein.

"These results may also contribute to the development of combined antibody therapies for SARS-CoV-2 as well as other viral diseases such as HIV by targeting unconventional viral proteins that are not typically targeted by monoclonal antibody therapies," said co-corresponding author Pablo Penaloza-MacMaster, Ph.D., assistant professor of Microbiology-Immunology.
User avatar
wjfox
Site Admin
Posts: 8666
Joined: Sat May 15, 2021 6:09 pm
Location: London, UK
Contact:

Re: COVID-19 News and Discussions

Post by wjfox »

User avatar
wjfox
Site Admin
Posts: 8666
Joined: Sat May 15, 2021 6:09 pm
Location: London, UK
Contact:

Re: COVID-19 News and Discussions

Post by wjfox »

If you had COVID, several of your organs could be aging 3-4 years faster: Study

Tuesday, October 18, 2022 5:01PM

SAN FRANCISCO -- After over two and a half years of COVID research, scientists are seeing the first data points that prove a dramatic change in human organs after a COVID infection.

"You can start thinking about getting COVID as almost as an accelerant to aging. The viral infection accelerates the aging process in people," said Dr. Ziyad Al-Aly, director of the Clinical Epidemiology Center at Washington University in St. Louis and the chief of research and education service at Veterans Affairs St. Louis Health Care System.

Dr. Al-Aly gathered data from millions of people across the country. Their studies on kidney outcomes in long COVID, long COVID in the brain and long COVID in the heart had similar patterns.

All pointing to multiple human organs aging faster after COVID. The majority happening among people who were hospitalized but also some with mild COVID symptoms.

"Almost by three to four years in the span of just one," said Dr. Al-Aly and added, "What we have seen is that people are losing about three to four percent kidney function in the year that follows that infection. That usually happens with aging. Three to four years of aging."

https://abc7news.com/covid-long-haul-st ... /12340213/
User avatar
Cyber_Rebel
Posts: 331
Joined: Sat Aug 14, 2021 10:59 pm
Location: New Dystopios

Re: COVID-19 News and Discussions

Post by Cyber_Rebel »

Hope that it accelerates 3D printing of organs as well then. The only way to get society back and people fully healthy again is by investing (heavily) into anti-aging research and 3D printing not just replicated organs, but overall superior ones.
User avatar
Ken_J
Posts: 241
Joined: Sun May 16, 2021 5:25 pm

Re: COVID-19 News and Discussions

Post by Ken_J »

wjfox wrote: Wed Oct 19, 2022 9:44 am If you had COVID, several of your organs could be aging 3-4 years faster: Study

Tuesday, October 18, 2022 5:01PM

SAN FRANCISCO -- After over two and a half years of COVID research, scientists are seeing the first data points that prove a dramatic change in human organs after a COVID infection.

"You can start thinking about getting COVID as almost as an accelerant to aging. The viral infection accelerates the aging process in people," said Dr. Ziyad Al-Aly, director of the Clinical Epidemiology Center at Washington University in St. Louis and the chief of research and education service at Veterans Affairs St. Louis Health Care System.

Dr. Al-Aly gathered data from millions of people across the country. Their studies on kidney outcomes in long COVID, long COVID in the brain and long COVID in the heart had similar patterns.

All pointing to multiple human organs aging faster after COVID. The majority happening among people who were hospitalized but also some with mild COVID symptoms.

"Almost by three to four years in the span of just one," said Dr. Al-Aly and added, "What we have seen is that people are losing about three to four percent kidney function in the year that follows that infection. That usually happens with aging. Three to four years of aging."

https://abc7news.com/covid-long-haul-st ... /12340213/
it seems that the situation is specific to hospitalized and long covid sufferers, not literally everyone who had it. and they are seeing evidence that what signs of it they have seen are not persistent but 'levels off' after a while. and given that most of the sample they are using for the assessment were infected within the last year and a half... this comes across as just fear mongering.

How much does a standard viral infection risk in aging the body and for what length of time does the effect persist in the patient? Flu, Mono, the common cold. They all add wear and tear to the system and for those who get a case that lasts longer or get more severe , requiring hospitalization, the deteriorization of the body can be severe and take a great deal of time to recover from.

I've an uncle who as a child got a fever. He's been deaf in one ear ever since, and has some kidney issues likely due in part to that sickness. he's a doctor and has always taken good care of his health. he's in his early seventies now and likely to make it to his eighties at least.
weatheriscool
Posts: 12727
Joined: Sun May 16, 2021 6:16 pm

Re: COVID-19 News and Discussions

Post by weatheriscool »

CDC director tests positive for Covid-19
Source: CNN
CNN — Dr. Rochelle Walensky, the director of the US Centers for Disease Control and Prevention, tested positive for Covid-19 on Friday. Walensky is experiencing mild symptoms and is up to date on her Covid-19 vaccines, according to a statement released by the agency. Walensky received an updated Covid-19 booster in September.

“Consistent with CDC guidelines, she is isolating at home and will participate in her planned meetings virtually,” the agency said. “CDC senior staff and close contacts have been informed of her positive test and are taking appropriate action to monitor their health.” Covid-19 cases have been falling as the United States moves into fall. However, experts say cases may begin to climb as they have during the past two pandemic winters – especially as several new coronavirus variants begin to gain traction.

The CDC recommends that people who have recently recovered from a Covid-19 infection wait to get boosted at least until the illness has passed and a person is no longer contagious. The CDC says a person “may consider delaying your vaccine by 3 months from when your symptoms started.”

Getting infected can act like a booster, and studies have shown that people have a relatively low risk of getting sick again for about three months after they recover. People may not want to wait as long as three months if Covid-19 levels are high in the community or they have a reduced immune function, CNN has reported.
Read more: https://www.cnn.com/2022/10/22/health/c ... index.html
User avatar
raklian
Posts: 1746
Joined: Sun May 16, 2021 4:46 pm
Location: North Carolina

Re: COVID-19 News and Discussions

Post by raklian »

We may have a flying HIV in our midst. :?

To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
User avatar
wjfox
Site Admin
Posts: 8666
Joined: Sat May 15, 2021 6:09 pm
Location: London, UK
Contact:

Re: COVID-19 News and Discussions

Post by wjfox »

^ Old study from July 2020, before vaccines and boosters.
User avatar
raklian
Posts: 1746
Joined: Sun May 16, 2021 4:46 pm
Location: North Carolina

Re: COVID-19 News and Discussions

Post by raklian »

wjfox wrote: Tue Oct 25, 2022 9:05 am ^ Old study from July 2020, before vaccines and boosters.
Yes, it's just a reminder that Covid is not the flu or a cold. People are becoming too complacent again.

Besides, there's talk that vaccines or boosters may not entirely stop the immunocompromising effects of Covid. I do not know if there is any merit to it, but I hope there is an ongoing research to see if it holds any water.
To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
User avatar
caltrek
Posts: 6474
Joined: Mon May 17, 2021 1:17 pm

Re: COVID-19 News and Discussions

Post by caltrek »

How Severe is the SARS-CoV-2 Omicron BA.2 Subvariant Compared with Earlier Variants?
October 26, 2022

Introduction:
(EurekAlert) Investigators determined that the BA.2 subvariant is less severe than the previous Delta variant and less severe to an even greater extent than the original Omicron variant

Key Takeaways

• In an analysis of COVID-19 cases from Mass General Brigham’s electronic health record system, mortality rates were 0.7% for the SARS-CoV-2 Delta variant, 0.4% for the original Omicron variant, and 0.3% for the Omicron BA.2 subvariant

• After adjustments, the odds of death were more than 2-times higher for the Delta and original Omicron variants compared with Omicron BA.2

• Patients with Delta and original Omicron variants were also more likely to need hospitalizations, invasive ventilation, and intensive care admissions

• The comprehensive digital surveillance system can continue to be used to measure SARS-CoV-2’s intrinsic severity over time
Read more of the EurekAlert[/] article here: https://www.eurekalert.org/news-releases/969273
The results of the study as presented in an article of the JAMA Network Open can be read here: https://jamanetwork.com/journals/jaman ... e/2797625
Don't mourn, organize.

-Joe Hill
Post Reply