A vaccine to eliminate aged cells
12th December 2021
Japanese researchers have demonstrated a vaccine to remove senescent cells in mice. These so-called "zombie cells" are a key driver behind the aging process.
[...]
Crucially, the team reports that their new vaccine has fewer negative side effects than previous anti-senescent cell treatments, while also lasting longer.
https://www.futuretimeline.net/blog/202 ... e-mice.htm
Aging & Longevity News and Discussions
Re: Aging & Longevity News and Discussions
I expect we'll start to seeing more robust anti-aging vaccines in the years to come. In a few decades, I predict governments will mandate anti-aging vaccines just like they do with vaccines against diseases today. The justification they will use is that those vaccines will tremendously reduce healthcare costs for geriatric care as well as the treatment of diseases that are highly correlated with the aging process.
To know is essentially the same as not knowing. The only thing that occurs is the rearrangement of atoms in your brain.
Re: Aging & Longevity News and Discussions
A vaxx worth taking. Sign me up.
Jokes aside, this sort of thing is on my wishlist for christmas 2030 when I'd be reaching my 40s and aging effects would start to kick more dramatically.
And, as always, bye bye.
Re: Aging & Longevity News and Discussions
^^^Message says: "This Tweet is unavailable."
Some-times certain content is blocked across borders, or there could be recent technical difficulties.
Some-times certain content is blocked across borders, or there could be recent technical difficulties.
Don't mourn, organize.
-Joe Hill
-Joe Hill
Re: Aging & Longevity News and Discussions
Seems he deleted the original, and then reposted as a reply elsewhere. I've edited my post with his (new) tweet, which contains the same graph.
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Re: Aging & Longevity News and Discussions
New research links genes to a longer human lifespan
https://medicalxpress.com/news/2022-01- ... espan.html
by University College London
https://medicalxpress.com/news/2022-01- ... espan.html
by University College London
A group of genes that play an essential role in building components of our cells can also impact human lifespan, finds a new study led by UCL researchers.
The genes have previously been found to extend lifespan in small organisms, such as making fruit flies live 10% longer, but this is the first time scientists have demonstrated a link in people as well, as they report in a new Genome Research paper.
Co-lead author Dr. Nazif Alic (UCL Institute of Healthy Ageing) said, "We have already seen from extensive previous research that inhibiting certain genes involved in making proteins in our cells, can extend lifespan in model organisms such as yeast, worms and flies. However, in humans, loss of function in these genes has been seen to cause diseases, such as developmental disorders known as ribosomopathies.
"Here, we have found that inhibiting these genes may also increase longevity in people, perhaps because they are most useful early in life before causing problems in late life."
The genes are involved in the protein synthetic machinery of our cells, which is essential for life, but the researchers say it may be that we do not need as much of its effect late in life. The genes appear to be an example of antagonistic pleiotropy, where genes that shorten our lives are selected for in evolution if they help us early in life and through our child-bearing years.
The researchers reviewed genetic data from previous studies involving 11,262 people who had lived an exceptionally long life, to an age above the 90th percentile of their cohort. They found that people with reduced activity of certain genes were more likely to live very long lives. The genes are linked to two RNA polymerase enzymes (Pols) that transcribe ribosomal and transfer RNAs, namely Pol I and Pol III, as well as the expression of ribosomal protein genes.
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Re: Aging & Longevity News and Discussions
Cellular rejuvenation therapy safely reverses signs of aging in mice
https://medicalxpress.com/news/2022-03- ... erses.html
by Salk Institute
https://medicalxpress.com/news/2022-03- ... erses.html
by Salk Institute
Age may be just a number, but it's a number that often carries unwanted side effects, from brittle bones and weaker muscles to increased risks of cardiovascular disease and cancer. Now, scientists at the Salk Institute, in collaboration with Genentech, a member of the Roche group, have shown that they can safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states.
"We are elated that we can use this approach across the life span to slow down aging in normal animals. The technique is both safe and effective in mice," says Juan Carlos Izpisua Belmonte, co-corresponding author and a professor in Salk's Gene Expression Laboratory. "In addition to tackling age-related diseases, this approach may provide the biomedical community with a new tool to restore tissue and organismal health by improving cell function and resilience in different disease situations, such as neurodegenerative diseases."
As organisms age, it is not just their outward appearances and health that change; every cell in their bodies carries a molecular clock that records the passage of time. Cells isolated from older people or animals have different patterns of chemicals along their DNA—called epigenetic markers—compared to younger people or animals. Scientists know that adding a mixture of four reprogramming molecules—Oct4, Sox2, Klf4 and cMyc, also known as "Yamanaka factors"—to cells can reset these epigenetic marks to their original patterns. This approach is how researchers can dial back adult cells, developmentally speaking, into stem cells.