mRNA Treatment

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Yuli Ban
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Re: mRNA Treatment

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Biontech is using part of their revenue from the covid vaccine to develop a Malaria vaccine, could be mass produced by 2023
The Mainz-based pharmaceutical manufacturer Biontech is starting the development of a vaccine against malaria: with the aim of producing the world's first vaccine against this disease based on mRNA technology. According to SPIEGEL information, the Biontech founders Uğur Şahin and Özlem Türeci want to announce this this Monday afternoon at an event organized by the non-profit kENUP Foundation.

Accordingly, Biontech plans to start clinical trials of its new malaria vaccine as early as next year. The drug could then possibly be administered en masse in 2023 or 2024. So far there is only one approved vaccine worldwide with limited effectiveness against plasmodia, the causative agent of malaria.
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Yuli Ban
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Re: mRNA Treatment

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Moderna to begin human trials of HIV mRNA vaccines by the end of the year
Moderna, a US biotechnology company that develops messenger RNA drugs, will test two HIV mRNA vaccines in humans at once. Clinical trials will start before the end of 2021.

Two experimental vaccines, Moderna mRNA-1644 and mRNA-1644v2-Core, have passed phase I testing, according to a publication on the NIH-operated website ClinicalTrials.gov. The randomized trial, conducted for the first time in humans, will recruit about 56 adults between the ages of 18 and 50. Some of the volunteers are infected with the human immunodeficiency virus. The study is expected to be completed around May 2023.
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Yuli Ban
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Re: mRNA Treatment

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Moderna's mRNA Vaccine for HIV Is Starting Human Trials This Week
Before 2020, many of us had never heard of mRNA. With the development of Covid-19 vaccines dependent on this molecule, though, mention of it was all over the news. In early August, the US reached the milestone of 70 percent of adults having received at least one dose of the vaccine. Covid was the first disease mRNA therapeutics tackled, and given the success of the Pfizer and Moderna vaccines at preventing severe cases of the virus, it won’t be the last.

New candidates are lining up, with scientists saying mRNA could make it possible to develop vaccines against all kinds of diseases that, until now, haven’t had a solution in sight. One of these is HIV; Moderna (whose name, by the way, comes from “modified RNA”) started trials of its experimental mRNA-based HIV vaccine, called mRNA-1644, this week.

The Phase 1 trial will consist of giving the vaccine to 56 adults who don’t have HIV, with the primary goals being to evaluate its safety and monitor the development of an immune response in participants. In addition to the initial version of the vaccine, Moderna developed a variant called mRNA-1644-v2-Core.

As detailed in Moderna’s August 11 submission to the to the National Institutes of Health’s Clinical Trials registry, participants in the trial will be split into four different groups, with one group getting mRNA-1644, a second group getting mRNA-1644-v2, and the remaining two groups getting a mix of both versions. Rather than a blind trial, where people don’t know which injection they’re receiving, participants will be aware of what they’re getting.

This first phase of the clinical trial is scheduled to take around 10 months, and will be followed by Phase 2 and 3 trials.
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Yuli Ban
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Re: mRNA Treatment

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As I've been saying: mRNA treatment is one of the biggest breakthroughs in modern science, and it's ongoing right now! We should all be excited for the near future.
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