Re: Aging & Longevity News and Discussions
Posted: Sat Jan 07, 2023 11:48 pm
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Just wow. Now I'm starting to think it will be definitely possible to reverse at least some aspects of aging in our lifetime.
In the Cell paper, Sinclair and his team report that not only can they age mice on an accelerated timeline, but they can also reverse the effects of that aging and restore some of the biological signs of youthfulness to the animals. That reversibility makes a strong case for the fact that the main drivers of aging aren’t mutations to the DNA, but miscues in the epigenetic instructions that somehow go awry. Sinclair has long proposed that aging is the result of losing critical instructions that cells need to continue functioning, in what he calls the Information Theory of Aging. “Underlying aging is information that is lost in cells, not just the accumulation of damage,” he says. “That’s a paradigm shift in how to think about aging. “
Read more here: https://medicalxpress.com/news/2023-01 ... ging.html(Medical Xpress) Researchers have found that the drug rilmenidine can extend lifespan and slow aging.
Published in Aging Cell, the findings show that animals treated with rilmenidine, currently used to treat hypertension, at young and older ages increases lifespan and improves health markers, mimicking the effects of caloric restriction.
They also demonstrate that the healthspan and lifespan benefits of rilmenidine treatment in the roundworm C. elegans are mediated by the I1-imidazoline receptor nish-1, identifying this receptor as a potential longevity target.
Unlike other drugs previously studied for this purpose by the researchers, the widely-prescribed, oral antihypertensive rilmenidine has potential for future translatability to humans as side-effects are rare and non-severe.
To date, a caloric restriction diet has been considered the most robust anti-aging intervention, promoting longevity across species. However, studies of caloric restriction in humans have had mixed results and side effects, meaning finding medications like rilmenidine that can mimic the benefits of caloric restriction is the most reasonable anti-aging strategy.
Injecting the genes of so-called “super-agers” into failing heart cells regenerates them, making them function as if they were 10 years younger, scientists have found.
The discovery opens the door for heart failure to be treated or prevented by reprogramming damaged cells.
Researchers have long suspected that people who live beyond 100 years old must have a unique genetic code that protects them from the ravages of old age.
Previous research showed that carriers of a variant of the BP1FB4 gene enjoy long lifespans and fewer heart problems.
In new experiments, scientists from the University of Bristol inserted the gene variant into a harmless virus and then injected it into elderly mice. They found that it rewound the heart’s biological clock by the human equivalent of 10 years.