Future Timeline

This doesn't sound very convincing to me.

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Ageing process is unstoppable, finds unprecedented study

Thu 17 Jun 2021 12.37 BST

Immortality and everlasting youth are the stuff of myths, according to new research which may finally end the eternal debate about whether we can live for ever.

Backed by governments, business, academics and investors in an industry worth $110bn (£82.5bn) – and estimated to be worth $610bn by 2025 – scientists have spent decades attempting to harness the power of genomics and artificial intelligence to find a way to prevent or even reverse ageing.

But an unprecedented study has now confirmed that we probably cannot slow the rate at which we get older because of biological constraints.

The study, by an international collaboration of scientists from 14 countries and including experts from the University of Oxford, set out to test the “invariant rate of ageing” hypothesis, which says that a species has a relatively fixed rate of ageing from adulthood.

“Our findings support the theory that, rather than slowing down death, more people are living much longer due to a reduction in mortality at younger ages,” said José Manuel Aburto from Oxford’s Leverhulme Centre for Demographic Science, who analysed age-specific birth and death data spanning centuries and continents.

https://www.theguardian.com/science/202 ... nted-study

wjfox wrote: ↑Fri Jun 18, 2021 4:40 pm This doesn't sound very convincing to me.

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Ageing process is unstoppable, finds unprecedented study

Even if it's true, it doesn't change the fact we still can repair the damage caused by the various processes that cause aging. That's why they call it "engineered negligible senescence."

None of the ant-aging proponents claimed the aging process can be stopped.

40% is very significant. Whether it will translate to humans remains to be seen, but if it's possible to extend the lifespan of a mammal by 40%, this opens up many avenues to longevity interventions that weren't possible just few years ago. If these results translate to humans, there is a chance our generation will get to live to 120s if we choose to undergo this treatment.

Things are starting to accelerate when respect to anti-aging rejuvenations. Maybe we should adopt something like Moore's Law but for measuring the increases to lifespans in time intervals.

raklian wrote: ↑Sun Jun 27, 2021 6:43 pmMaybe we should adopt something like Moore's Law but for measuring the increases to lifespans in time intervals.

isn't that what the longevity escape velocity is? Literally measuring the years extended per year of time passing. with a point at which less than a year goes by between years added.

raklian wrote: ↑Sun Jun 27, 2021 6:43 pm

Small sample size, and yet to be peer-reviewed, but a 40% increase would be huge. Equivalent to human lifespan increasing from 80 to ~112.

wjfox wrote: ↑Sun Jun 27, 2021 7:34 pm
Small sample size, and yet to be peer-reviewed, but a 40% increase would be huge. Equivalent to human lifespan increasing from 80 to ~112.

There was a commentary by another longevity researcher who isn't part of this study saying this news is significant. It's not exactly a proper peer-review but more like a tentative thumbs up.

Harvard Scientists Pinpoint ‘Ground Zero’ of Aging in Mouse Embryo Study

How do old cells in adult humans give rise to the youthful cells found in infants? New research suggests they reset to their lowest biological age in early embryonic development, with potential ramifications for longevity science.

For a long time, it was assumed that germline cells—those that form eggs and sperm and pass a parent’s genetic information on to their children—were essentially ageless. But how this could be was never clear and more recent research had shown that germline cells do accumulate the signs of aging.

This led to the conclusion that there must be some kind of rejuvenation event that allows the offspring’s cells to start with a clean slate. But when and how this occurs was a mystery.

Now a team from Harvard has shown that the age of mouse embryo cells resets about a week into development, representing the “ground zero” of aging. The finding not only provides insight into the fundamental dynamics of aging, but also suggests we might mimic the process in adult cells to rejuvenate aging tissues.