10 Years Since Announcement of CRISPR Discovery
Posted: Tue Jun 28, 2022 4:17 pm
Seems like there are a lot of articles this week coming out about CRISPR both future and past. Considering this has probably been one of the most significant developments in science this century. Thought it would be good to have a little post about what has been achieved so far with the technology and what is to come:
28 June 2012: Paper "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity" is published - https://www.science.org/doi/10.1126/science.1225829
3 January 2013: First use of CRISPR/CAS9 to edit human cells in a dish - https://pubmed.ncbi.nlm.nih.gov/23287718/s
2016: UC Berkeley vs Broad Institute CRISPR patent row begins - https://www.nature.com/articles/d41586-022-00629-y
2017: Courts side with Broad Institute in patent row - https://www.nature.com/articles/d41586-022-00629-y
September 2018: Appeals court also sides with Broad institute in patent row - https://www.nature.com/articles/d41586-022-00629-y
November 2018: He Jiankui causes international outrage after stating that he had genetically modified embryos with CRISPR and implanted them in women in an attempt to grant the children immunity from HIV - https://www.science.org/content/article ... years-jail
November 2018: World's first CRISPR genetically modified children are born - https://www.science.org/content/article ... years-jail
25 January 2019: Clinical trial of CRISPR derived treatment for Leber congenital amaurosis 10 beings - https://ir.editasmedicine.com/news-rele ... e-phase-12
25 February 2019: Clinical trial of CRISPR derived treatment for sickle cell disease and beta thalassemia beings - http://www.crisprtx.com/about-us/press- ... apy-ctx001
30 December 2019: He Jiankui jailed for "illegal medical practices" for 3 years - https://www.science.org/content/article ... years-jail
07 October 2020: Jennifer Doudna and Emmanuelle Charpentier awared the 2020 Nobel Prize in Chemistry - https://www.statnews.com/2020/10/07/two ... chemistry/
29 June 2021: CRISPR treatment shows promise against rare fatal liver disease transthyretin amyloidosis - https://www.nature.com/articles/d41586-021-01776-4
Predicted Upcoming Advances:
CRISPR treatments for genetic diseases, cancer, etc...
Gene trait editing on embryos
Gene drive to control mosquito populations (malaria control)
CRISPR driven biosynthesis of natural products (cool video below)
28 June 2012: Paper "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity" is published - https://www.science.org/doi/10.1126/science.1225829
3 January 2013: First use of CRISPR/CAS9 to edit human cells in a dish - https://pubmed.ncbi.nlm.nih.gov/23287718/s
2016: UC Berkeley vs Broad Institute CRISPR patent row begins - https://www.nature.com/articles/d41586-022-00629-y
2017: Courts side with Broad Institute in patent row - https://www.nature.com/articles/d41586-022-00629-y
September 2018: Appeals court also sides with Broad institute in patent row - https://www.nature.com/articles/d41586-022-00629-y
November 2018: He Jiankui causes international outrage after stating that he had genetically modified embryos with CRISPR and implanted them in women in an attempt to grant the children immunity from HIV - https://www.science.org/content/article ... years-jail
November 2018: World's first CRISPR genetically modified children are born - https://www.science.org/content/article ... years-jail
25 January 2019: Clinical trial of CRISPR derived treatment for Leber congenital amaurosis 10 beings - https://ir.editasmedicine.com/news-rele ... e-phase-12
25 February 2019: Clinical trial of CRISPR derived treatment for sickle cell disease and beta thalassemia beings - http://www.crisprtx.com/about-us/press- ... apy-ctx001
30 December 2019: He Jiankui jailed for "illegal medical practices" for 3 years - https://www.science.org/content/article ... years-jail
07 October 2020: Jennifer Doudna and Emmanuelle Charpentier awared the 2020 Nobel Prize in Chemistry - https://www.statnews.com/2020/10/07/two ... chemistry/
29 June 2021: CRISPR treatment shows promise against rare fatal liver disease transthyretin amyloidosis - https://www.nature.com/articles/d41586-021-01776-4
Predicted Upcoming Advances:
CRISPR treatments for genetic diseases, cancer, etc...
Gene trait editing on embryos
Gene drive to control mosquito populations (malaria control)
CRISPR driven biosynthesis of natural products (cool video below)
