Aging & Longevity News and Discussions

[weatheriscool]

Researchers successfully rejuvenate aging livers in preclinical study
https://www.medicalnewstoday.com/articl ... ecd14afdea

Researchers have been able to reverse age-related damage to liver cells in mice and in human cell cultures in a new study.
The study homes in on ferroptosis — a form of iron-dependent cell death — as an age-related process affecting a set of key cells in the liver, called ‘hepatocytes.’
Its authors found gene clusters associated with this process in both mice and human cells.
The takeaway is that it may be possible to reverse aging in affected liver cells through pharmaceutical interventions.

A new study in mice and human cell samples finds that it may be possible to undo some of the damage that occurs with aging, restoring the liver at least partially to health.

The authors of the study found an abundance of genes that cause cell death in liver cells from older mice, and in human cells.

The age-related genes cause an iron-dependent type of cell death called ferroptosisTrusted Source. Ferroptosis is also implicated in damage to the heart, kidneys, and pancreatic islets.

[weatheriscool]

Anti-aging drug extends life up to 25%, staves off frailty and disease
By Bronwyn Thompson
July 18, 2024
https://newatlas.com/medical/anti-aging-interleukin-11/

For the first time, scientists have demonstrated how a specific protein increases in our organs as we get older and actively promotes the aging process. By blocking this activity, it could not only help us live longer, but slow the physical decline that is, right now, an inevitable part of aging.

Researchers at Duke-NUS Medical School in Singapore have previously undertaken three different studies to examine interleukin-11 (IL-11) protein expression and its role in heart and kidney, liver and lung health. The lattermost research has led to an experimental anti-IL-11 therapy that's currently in clinical trials to treat fibrotic lung disease.

Building on this work, the team identified IL-11's role in the aging process, with its increased production leading to fat accumulating in the liver and abdomen, as well as reduced muscle mass and strength. By blocking this protein expression, these hallmarks of aging could be drastically reduced.

[weatheriscool]

Blocking IL-11 Gene Reduces Inflammation So Mice Live 24% Longer and Healthier
July 20, 2024 by Brian Wang

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan- Nature

Female Il11-deleted mice are protected from age-associated obesity, frailty, and metabolic decline. Male mice lives 22.5% longer and female mice 25% longer.

The effects were similar to rapamycin but had less negative effects on liver and other organs when rapamycin is used for extended times.

For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark. Here they examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan. As mice age, IL-11 is upregulated across cell types and tissues to regulate an ERK–AMPK–mTORC1 axis to modulate cellular, tissue- and organismal-level ageing pathologies. Deletion of Il11 or Il11ra1 protects against metabolic decline, multi-morbidity and frailty in old age. Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and muscle function, and reduces ageing biomarkers and frailty across sexes. In lifespan studies, genetic deletion of Il11 extended the lives of mice of both sexes, by 24.9% on average. Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%. Together, these results demonstrate a role for the pro-inflammatory factor IL-11 in mammalian healthspan and lifespan. We suggest that anti-IL-11 therapy, which is currently in early-stage clinical trials for fibrotic lung disease, may provide a translational opportunity to determine the effects of IL-11 inhibition on ageing pathologies in older people.

https://www.nextbigfuture.com/2024/07/b ... thier.html

[weatheriscool]

I believe we're at least 30 years away from any kind of vaccine, pill or genetic engineering anti-aging that can reliably extend life here in the United states. Reliably as in 25+ years on the avg life span in humans that is approved by the fda. If the republicans continue to win then it will likely come from china, india or some other place in europe and will never get approved in the United states....The later could be more like 50-75 years.

Sure, mice, fruit fries gives me some serious hope that this could be done in humans, but you have consider the reality that there's no real human testing on such and probably won't be for years to come. This will be very slow process because of the fucking fda and the process. At the end of the day I want to believe that it can be done and will be done but some of us will be older then hell.

I wish some doctor would test it in secret and do what is necessary. Sometimes I believe the system is too regulated for its own good.

[firestar464]

Nah we gonna get bioshock

Also just wait a bit and ASI gonna figure it out. Patience is key here.

[weatheriscool]

Team finds that regenerative genes from other species suppress aging issue in fruit flies
https://phys.org/news/2024-07-team-rege ... press.html
by University of Tokyo

A team of researchers, including colleagues from the University of Tokyo's Graduate School of Pharmaceutical Sciences, have transferred into common fruit flies genes from simple organisms capable of regenerating their bodies. Fruit flies are more complex animals that cannot regenerate their bodies. The team found that the transferred gene suppressed an age-related intestinal issue in the flies. Their results suggest that studying genes specific to animals with high regenerative capability may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.

The work appears in BMC Biology.

Do you want to live forever? Some do, some don't. But we all want to live healthily for however long we have, and a big part of medical research is about this aspect of longevity. One idea, which might sound a little like science fiction, is to upgrade the human body in such a way that it can regenerate itself when injured, diseased, or when aging starts taking its toll, a bit like the superhero character Wolverine from the popular comic book and film series "X-Men." Of course, we're nowhere near that stage yet, but progress is being made in the world of regenerative medicine, albeit the test subjects are just flies for now.

[Yuli Ban]

https://podcasts.apple.com/us/podcast/b ... 0664967607

In this life-enhancing episode, Matt and Chris venture into the futuristic world of tech entrepreneur and biohacker Bryan Johnson, clarifying along the way that he’s not the ACDC frontman.

They examine Johnson's Project Blueprint and 'Don't Die' movement—a quest for indefinite lifespan extension through supplements and lifestyle changes—and consider whether their apprehension means they are actually death lovers gorging themselves each day on death burgers and life-draining whiskey.

The decoders analyze his carefully crafted appearance and branding, considering how he presents himself as a revolutionary figure but in reality seems to be peddling some familiar tropes, along with a supplement line and some expensive blueberries.

As usual, they consider the rhetorical moves, parasocial manipulations, and the likelihood for the lofty claims to become a reality.

One thing that is clear by the end: Bryan Johnson is certainly not a modern-day vampire.

[Yuli Ban]

[weatheriscool]

Common drug restores youthful function to clean up aging brains
By Michael Franco
August 15, 2024

A drug used to induce labor in pregnant women has been shown to reactivate tiny waste-clearing pumps in the brains of old mice. The finding could hold promise as a new way to fight Alzheimer's and Parkinson's diseases and overall cognitive decline.

When our brains are working properly, there is an excess of proteins that build up from the energy intensive processes that take place between our neurons. Those proteins need to be removed in order for the brain to continue to operate properly. When they aren't, they can gunk up the works, leading to the beta amyloid and tau protein tangles that are a hallmark of Alzheimer's disease or the build up of alpha-synuclein that accompanies Parkinson's.

https://newatlas.com/health-wellbeing/p ... rug-brain/

[firestar464]

Study finds potential link between DNA markers and aging process

https://medicalxpress.com/news/2024-08- ... aging.html

[wjfox]

Equivalent to somebody born today living until 6th February 2142.

-----

World’s oldest person, Maria Branyas Morera, dies aged 117

Supercentenarian who died in her sleep had lived through two world wars and Spain’s civil war

Tue 20 Aug 2024 13.00 BST

https://www.theguardian.com/world/artic ... s-aged-117

[Powers]

Equivalent to somebody born today living until 6th February 2142.

Little honestly with these dates.

[weatheriscool]

[Cyber_Rebel]

Literally just saw that vid in my feed and had Kyle's exact reaction to it.

So... is this the beginning of the anti-aging age? Will's timeline certainly is conservative on this front, but it almost appears to be on as much an exponential curve as AI in its own way. At least regarding our understanding of the aging process. I suppose we'll have to wait until the trial is finished, but human trials so soon are almost insane unless they were that confident in its efficacy. Society as we know it would be transformed even if an aging "slowdown" pill were discovered, as the idea of being within one's prime years for much longer would have drastic effects across many economies. Think Japan's in particular.

More on the story:

Telomir Pharmaceuticals Featured in Local ABC Exclusive Showing Positive Outcomes of Proposed Age Reversal Pill in Dogs
Promising results with Telomir-1 Demonstrates Potential in Promoting Life Quality and Longevity in Senior Dogs
August 20, 2024 7:30 am EDT

Source

TAMPA, FL / ACCESSWIRE / August 20, 2024 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) ("Telomir" or the "Company"), a pre-clinical-stage company seeking to lead developments in longevity science through the treatment of age-related conditions, is proud to announce that its novel small molecule, Telomir-1, was recently featured in an exclusive local ABC television news segment highlighting promising "age reversal" outcomes in two senior dogs.

The use of Telomir-1 in these two dogs was observed by Telomir's special advisor Dr. Michael Roizen, the former Chief Wellness Officer of the Cleveland Clinic and a leader in age-related medicine. In this small compassionate use program, remarkable improvements in the health and vitality of the dogs after treatment with Telomir-1 was noted, offering a glimpse into the potential future applications for humans.

In the segment, "ABC7 Exclusive: New study reveals promising results for age reversal pill on dogs," the transformative potential of Telomir-1 was showcased through the stories of Zeus and Benson, two senior dogs from Donte's Den rescue organization in Myakka City, Florida. After being treated with Telomir-1, both dogs exhibited significant improvements in their health conditions. Zeus, a 12-year-old German Shepherd, showed complete remission of terminal cancer, while Benson, a 12-year-old Newfoundland suffering from severe arthritis, regained his mobility, leading to what caretakers described as a miraculous recovery.

Erez Aminov, the newly appointed Chairman CEO of Telomir Pharmaceuticals, expressed his commitment to advancing the science behind Telomir-1 and accelerating its path to market.

Another commentary from The Japan Times regarding David Sinclair's work on age reversal in dogs, which might be somewhat similar to the above study.

https://www.japantimes.co.jp/commentary ... ging-drug/

[firestar464]

What accelerates brain ageing? This AI ‘brain clock’ points to answers

https://www.nature.com/articles/d41586-024-02770-2

[wjfox]

[firestar464]

4

[weatheriscool]

At this point we really do need to demand that the government hold these companies accountable for their greed.

[firestar464]

For more on what's happening with Ozempic:

https://www.fastcompany.com/91071415/yo ... says-study

[wjfox]

MRI scans of brain volume in 362 healthy adults across lifespan

Source: https://longevitygl.substack.com/p/is-o ... eplaceable