Aging & Longevity News and Discussions

[wjfox]

[weatheriscool]

Study hints at ways to generate new neurons in old brains
https://medicalxpress.com/news/2024-10- ... rains.html
by Stanford University Medical Center

Most neurons in the human brain last a lifetime, and for good reason. Intricate, long-term information is preserved in the complex structural relationships between their synapses. To lose the neurons would be to lose that critical information—that is, to forget.

Intriguingly, some new neurons are still produced in the adult brain by a population of cells called neural stem cells. As brains age, however, they become less and less adept at making these new neurons, a trend that can have devastating neurological consequences, not just for memory, but also for degenerative brain diseases such as Alzheimer's and Parkinson's and for recovery from stroke or other brain injury.

A new Stanford Medicine study, published Oct. 2 in Nature, sheds hopeful new light on how and why neural stem cells, the cells behind the generation of new neurons in the adult brain, become less active as brains age.

[wjfox]

[firestar464]

BRUHHHH

[weatheriscool]

I believe genetics is probably 90% of the difference between a avg life span of 70 and one that is 90. The later also has far better standards of life...What we do is find the genetics for the later and make it the standard across our species...Booom, 20 years of extra life with higher standards of life!

Next we find ways to enhance this and maybe even slow the process down.

I look at Reagan, Trump and people that live into their 90's and they have family that do it and can plan their lives around doing so....Unless something bad happens! On the other hand people that have parents dying in the 50's and 60's from strokes and heartattacks can plan on a much shorter life on the means.

[wjfox]

I believe genetics is probably 90% of the difference between a avg life span of 70 and one that is 90.

Studies have shown they account for only 20-30% of the variation in lifespan.

[wjfox]

New skin research could help slow signs of ageing

16 October 2024

Researchers have made a scientific discovery that in time could be used to slow the signs of ageing.

A team has discovered how the human body creates skin from a stem cell, and even reproduced small amounts of skin in a lab.

The research is part of a study to understand how every part of the human body is created, one cell at a time.

As well as combatting ageing, the findings could also be used to produce artificial skin for transplantation and prevent scarring.

The Human Cell Atlas project is one of the most ambitious research programmes in biology. It is international but centred at the Wellcome Sanger Institute in Cambridge.

https://www.bbc.co.uk/news/articles/c756q166gd9o

[caltrek]

Researchers Uncover New Function of a Protein that May Unlock Age-related Illnesses
October 17, 2024

Introduction:

(Eurekalert) Hamilton, ON, Oct. 17, 2024 – McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall.

The team has found that a class of protective proteins known as MANF plays a role in the process that keep cells efficient and working well.

Additional extract:

Our cells make proteins and discard them after they perform their jobs. This efficient, continuous maintenance process is known as cellular homeostasis. However, as we age, our cells’ ability to keep up declines.

Cells can create proteins incorrectly, and the cleanup process can become faulty or overwhelmed. As a result, proteins can clump together, leading to a harmful buildup that has been linked to such diseases as Alzheimer’s and Parkinson’s.

Read more here: https://www.eurekalert.org/news-releases/1061803

Study Abstract:

The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) is known for protecting dopaminergic (see definition below) neurons and functioning in various other tissues. Previously, we showed that Caenorhabditis elegans manf-1 null mutants exhibit defects such as increased endoplasmic reticulum (ER) stress, dopaminergic neurodegeneration, and abnormal protein aggregation. These findings suggest an essential role for MANF in cellular processes. However, the mechanisms by which intracellular and extracellular MANF regulate broader cellular functions remain unclear. We report a unique mechanism of action for MANF-1 that involves the transcription factor HLH-30/TFEB-mediated signaling to regulate autophagy (see definition below) and lysosomal function (see definition of lysome below). Multiple transgenic strains overexpressing MANF-1 showed extended lifespan of animals, reduced protein aggregation, and improved neuronal survival. Using fluorescently tagged MANF-1, we observed tissue-specific localization of the protein, which was dependent on the ER retention signal. Further subcellular analysis showed that MANF-1 localizes within cells to the lysosomes and utilizes the endosomal pathway. Consistent with the lysosomal localization, our transcriptomic study of MANF-1 and analyses of autophagy regulators demonstrated that MANF-1 promotes proteostasis (see definition below) by regulating autophagic flux and lysosomal activity. Collectively, our findings establish MANF as a critical regulator of stress response, proteostasis, and aging.

Source: https://www.pnas.org/doi/10.1073/pnas.2403906121

Dopaminergic neurons…(are) the specialized cells that produce and release dopamine, a neurotransmitter crucial for a wide array of brain functions.

Source: https://neurolaunch.com/dopaminergic-n ... ticulum /

Autophagy: (A) natural mechanism, often triggered by fasting, (that) allows our bodies to clean out damaged cells and regenerate new ones.

.
Source: https://austinmdclinic.com/what-is-aut ... -to-knpw/

(The) Lysosome, (is a) subcellular organelle that is found in nearly all types of eukaryotic cells (cells with a clearly defined nucleus) and that is responsible for the digestion of macromolecules, old cell parts, and microorganisms.

Source: https://www.britannica.com/science/lysosome

Proteostasis is the dynamic regulation of a balanced, functional proteome. The proteostasis network includes competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell.[1][2] Loss of proteostasis is central to understanding the cause of diseases associated with excessive protein misfolding and degradation leading to loss-of-function phenotypes,[3] as well as aggregation-associated degenerative disorders.[4] Therapeutic restoration of proteostasis may treat or resolve these pathologies.[5]

Cellular proteostasis is key to ensuring successful development, healthy aging, resistance to environmental stresses, and to minimize homeostatic perturbations from pathogens such as viruses.[2] Cellular mechanisms for maintaining proteostasis include regulated protein translation, chaperone assisted protein folding, and protein degradation pathways. Adjusting each of these mechanisms based on the need for specific proteins is essential to maintain all cellular functions relying on a correctly folded proteome.

Source (includes footnote links): https://en.wikipedia.org/wiki/Proteostasis

[weatheriscool]

Donations to Important Antiaging Research Doubled in October
October 21, 2024 by Brian Wang

Donations from Didier Coeurnelle enable next phase of LEVF (Longevity escape velocity foundation) Robust Mouse Rejuvenation research program.

The initial donation of €200,000 (approximately $220,000) will be increased by a further €200,000 donations to LEVF during the month of October 2024 will be doubled. Donate to LEVF in the next 10 days to boost antiaging research.

These donations enable a key set of pre-study pilots ahead of the next phase of LEVF’s groundbreaking investigations into the effects of combining different damage-repair interventions for middle-aged mice.

https://www.nextbigfuture.com/2024/10/d ... tober.html

[raklian]

[weatheriscool]

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

by Holly Ober, University of California, Los Angeles

Humans aren't the only ones who grow forgetful as they age—fruit flies do, too. But because fruit flies have a lifespan of only about two months, they can be a useful model for understanding the cognitive decline that comes with aging.

A new study published in Nature Communications shows that when a common cell structural protein called filamentous actin, or F-actin, builds up in the brain, it inhibits a key process that removes unnecessary or dysfunctional components within cells, including DNA, lipids, proteins and organelles.

https://medicalxpress.com/news/2024-10- ... fruit.html

[weatheriscool]

Tweak to common cell protein gene extends healthy lifespan by 30%
By Paul McClure
November 02, 2024
https://newatlas.com/aging/actin-cytosk ... -extended/

Not only have researchers identified how a common cellular protein affects aging, but they’ve tweaked the genes that produce it in fruit flies, extending healthy lifespan by 25% to 30%. The discovery opens the door to healthier aging in humans.

The cytoskeleton provides most cells with their shape, structure, and internal organization. In turn, the cytoskeleton relies on a type of actin protein, called filamentous or F-actin. It forms networks of thin, flexible filaments that affect the shape, stiffness, and movement of cells. Studies have found that aging alters actin expression, disrupting the cytoskeleton’s functions, which can lead to age-related diseases, including cancer and neurodegenerative diseases.

A new study by UCLA researchers has investigated the role of actin in brain aging and found that when F-actin accumulates in the brain, it hinders cellular cleanup and leads to the buildup of waste that decreases neuronal functioning and contributes to cognitive decline. However, they also found that tweaking some genes in fruit flies prevented the build-up of F-actin and extended the flies’ healthy lifespan by around 30%.

[wjfox]

Billionaires are creating ‘life-extending pills’ for the rich — but CEO warns they’ll lead to a planet of ‘posh zombies’

Published Nov. 25, 2024, 9:49 a.m. ET

Billionaires are funding the creation of life-extending pills that will eventually hit the market for people to buy, according to a CEO — and he says it’ll turn the rich in to “posh, privileged zombies.”

[...]

“At the rate technology is evolving, it will only be a matter of time before life-extending drugs become freely available to those who can afford them,” said Phil Cleary, the founder of the SmartWater Group.

But Cleary said Silicon Valley moguls should “quit playing God” in their race to conquer death, calling the quest for the holy grail of medicine “ego-driven” and charging that it risks creating a planet of “posh, privileged zombies.”

Instead, he said, they should use their huge fortunes to help the world’s poorest children survive at least into adulthood. Rather than prolonging the lives of the rich elite, their money would be better spent on the world’s 5 million children who die of hunger and from other preventable, treatable causes every year.

“Silicon Valley’s dogged pursuit of the fountain of youth is a fear-led, ego-driven folly that comes at a terrible humanitarian cost to the planet and to its most vulnerable inhabitants,” said Cleary, the author of “Elixir,” a novel that explores the damaging consequences of life-extending drugs on society.

https://nypost.com/2024/11/25/lifestyle ... -says-ceo/

[weatheriscool]

Billionaires are creating ‘life-extending pills’ for the rich — but CEO warns they’ll lead to a planet of ‘posh zombies’

Published Nov. 25, 2024, 9:49 a.m. ET

Billionaires are funding the creation of life-extending pills that will eventually hit the market for people to buy, according to a CEO — and he says it’ll turn the rich in to “posh, privileged zombies.”

[...]

“At the rate technology is evolving, it will only be a matter of time before life-extending drugs become freely available to those who can afford them,” said Phil Cleary, the founder of the SmartWater Group.

But Cleary said Silicon Valley moguls should “quit playing God” in their race to conquer death, calling the quest for the holy grail of medicine “ego-driven” and charging that it risks creating a planet of “posh, privileged zombies.”

Instead, he said, they should use their huge fortunes to help the world’s poorest children survive at least into adulthood. Rather than prolonging the lives of the rich elite, their money would be better spent on the world’s 5 million children who die of hunger and from other preventable, treatable causes every year.

“Silicon Valley’s dogged pursuit of the fountain of youth is a fear-led, ego-driven folly that comes at a terrible humanitarian cost to the planet and to its most vulnerable inhabitants,” said Cleary, the author of “Elixir,” a novel that explores the damaging consequences of life-extending drugs on society.

https://nypost.com/2024/11/25/lifestyle ... -says-ceo/

Seriously, why can't we do both? Also why should such a pill cost this much unless it is meant only for the rich??? Shouldn't nations take action to force this pill to be at a reasonable price? I can understand research and development but that shouldn't mean it cost more then maybe 10 grand for a few years tops. No sorry but one should be allowed to live to 110 or 130. LIfe is too fucking short as it is. We can also help children live longer lives as the people of those nations need to wake the f*ck up in do just that. It is called giving a damn about your own nation and its people! Time to act like an adult and build your standards of living and care.

[wjfox]

Shouldn't nations take action to force this pill to be at a reasonable price?

I believe they will have to, at some point, due to declining populations and other demographic issues. Aubrey de Grey has predicted this too. China or some other Asian country will probably be the first to do it.

[firestar464]

I mean it is easier to just give everyone anti-aging meds instead of having to execute some sort of convoluted plan to kill everybody

[wjfox]

Daily nut consumption boosts healthy lifespan

25th November 2024

New research has found that eating nuts daily can reduce the risk of disability or death and extend healthy years, especially for older adults with suboptimal diets.

As populations worldwide continue to age, finding ways to promote health and independence in later life is becoming increasingly important. A new study published in Age and Ageing offers compelling evidence that a simple dietary habit – daily nut consumption – may significantly help in achieving this goal.

Conducted as part of the ASPREE Longitudinal Study of Older Persons, this research followed 9,916 community-dwelling adults aged 70 years and above over a four-year period. Participants were surveyed about their nut consumption habits, which ranged from infrequent (once a month or less) to daily.

The study found that daily nut eaters had a 23% lower risk of reaching a "composite endpoint" – a combined measure that included death, dementia, or persistent physical disability – compared to those who consumed nuts infrequently.

"Our study was able to account for poor oral health and other foods that people usually ate, and after adjusting for these and other factors, eating nuts remained positively associated with a healthy lifespan in later life," said first author Holly Wild, a PhD candidate and lecturer from Monash University, Australia.

Read more: https://www.futuretimeline.net/blog/202 ... fespan.htm

[firestar464]

Science- Shades of Blue

https://archive.ph/RdmZz

man what a shitshow

[weatheriscool]

[firestar464]

dude you alright

https://en.wikipedia.org/wiki/Jeremy_Kauffman