2nd March 2020
First non-oxygen breathing animal discovered
Scientists at Tel Aviv University report the discovery of the first non-oxygen breathing animal, Henneguya salminicola, a parasite that lives within salmon muscle.
Researchers at Tel Aviv University (TAU) have discovered a non-oxygen breathing animal. The unexpected finding changes one of science's most basic assumptions about the animal world.
Henneguya salminicola – a tiny parasite with fewer than 10 cells – is a myxozoan relative of jellyfish and corals. It lives in salmon muscle, and has evolved to produce energy without the need for breathing and consuming oxygen.
"Aerobic respiration was thought to be ubiquitous in animals, but now we confirmed that this is not the case," explains Professor Dorothee Huchon of the School of Zoology at TAU's Faculty of Life Sciences. "Our discovery shows that evolution can go in strange directions. Aerobic respiration is a major source of energy, and yet we found an animal that gave up this critical pathway."
Some other organisms like fungi, amoebas or ciliate lineages in anaerobic environments have lost the ability to breathe over time. The new study demonstrates that the same can happen to an animal – possibly because the parasite happens to live in an anaerobic environment. Its genome was sequenced, along with those of other myxozoan fish parasites, as part of research supported by the U.S.-Israel Binational Science Foundation.
The parasite's anaerobic nature was an accidental discovery. While assembling the Henneguya genome, Professor Huchon found that it did not include a mitochondrial genome. The mitochondria is the "powerhouse" of the cell where oxygen is captured to make energy, so its absence indicated that the animal was not breathing oxygen.
Until this new discovery, there was debate regarding the possibility that organisms belonging to the animal kingdom could survive within anaerobic environments. The assumption that all animals are breathing oxygen was based, among other things, on the fact that animals are multicellular, highly developed organisms, which first appeared on Earth when oxygen levels rose.
"It's not yet clear to us how the parasite generates energy," Prof. Huchon says. "It may be drawing it from the surrounding fish cells, or it may have a different type of respiration such as oxygen-free breathing, which typically characterises anaerobic non-animal organisms."
According to Prof. Huchon, the discovery bears enormous significance for evolutionary research.
"It is generally thought that during evolution, organisms become more and more complex – and that simple, single-celled, or few-celled organisms are the ancestors of complex organisms," she concludes. "But here, right before us, is an animal whose evolutionary process is the opposite. Living in an oxygen-free environment, it has shed unnecessary genes responsible for aerobic respiration and become an even simpler organism."
A study on the finding was published on 24th February in the journal PNAS.